Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation
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DOI: 10.1007/s11010-017-3129-3
Abstract: The aim of this work was the synthesis, characterization, and cytotoxicity evaluation of three new Ru(II) complexes with a general formula [Ru(Spy)(bipy)(P-P)]PF6 [Spy = pyridine-6-thiolate; bipy = 2,2′-bipyridine; P-P = 1,2-bis(diphenylphosphine)ethane (1); 1,3-bis(diphenylphosphine) propane (2); and 1,1′-bis(diphenylphosphino)ferrocene] (4). Complex (3) with… read more here.
Keywords: diphenylphosphine; pyridine thiolate; p53 bax; cell apoptosis ... See more keywords
Activated mitochondrial apoptosis in hESCs after dissociation involving the PKA/p‐p53/Bax signaling pathway
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DOI: 10.1016/j.yexcr.2018.05.024
Abstract: Abstract Human embryonic stem cells (hESCs) are highly fragile with massive cell death after dissociation into single cells, which seriously hampers their applications. The mechanism underlying the massive cell death after dissociation still remains elusive.… read more here.
Keywords: pka p53; bax signaling; apoptosis; dissociation ... See more keywords
Long non-coding RNA DINO promotes cisplatin sensitivity in lung adenocarcinoma via the p53-Bax axis
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DOI: 10.21037/jtd-23-465
Abstract: Background The damage-induced non-coding (DINO) RNA is a newly identified long non-coding RNA (lncRNA) found in human cells with DNA damage. The treatment of tumors with cisplatin can induce DNA damage; however, whether the lncRNA… read more here.
Keywords: dino; lung; p53 bax; p53 ... See more keywords