The role of p53 in cancer drug resistance and targeted chemotherapy
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13475
Abstract: Cancer has long been a grievous disease complicated by innumerable players aggravating its cure. Many clinical studies demonstrated the prognostic relevance of the tumor suppressor protein p53 for many human tumor types. Overexpression of mutated… read more here.
Keywords: role p53; p53 cancer; cancer; p53 ... See more keywords
Mutant p53 in Cancer Progression and Targeted Therapies
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.595187
Abstract: TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority of mutations of p53 are missense mutations, leading to the expression of the full length p53 mutant proteins. Mutant p53 (Mutp53)… read more here.
Keywords: mutant p53; cancer progression; p53 cancer; p53 ... See more keywords
Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12040548
Abstract: TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding transcription factor activated by stressful stimuli; it upregulates target genes involved in growth suppression, cell death, DNA repair, metabolism, among others. TP53 is the… read more here.
Keywords: mutant p53; p53 cancer; p53; targeting wild ... See more keywords
Gain of Function (GOF) Mutant p53 in Cancer—Current Therapeutic Approaches
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113287
Abstract: Continuous development of personalized treatments is undoubtedly beneficial for oncogenic patients’ comfort and survival rate. Mutant TP53 is associated with a worse prognosis due to the occurrence of metastases, increased chemoresistance, and tumor growth. Currently,… read more here.
Keywords: function gof; gain function; mutant p53; p53 ... See more keywords