Inhibition of HIV early replication by the p53 and its downstream gene p21
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DOI: 10.1186/s12985-018-0959-x
Abstract: BackgroundThe tumor suppressor gene p53 has been found to suppress HIV infection by various mechanisms, but the inhibition of HIV at an early stage of replication by host cell p53 and its downstream gene p21… read more here.
Keywords: hct116 p53; infection; inhibition; p53 cells ... See more keywords
p53-Mediated Oxidative Stress Enhances Indirubin-3′-Monoxime-Induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-Related Apoptosis-Inducing Ligand Expression
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DOI: 10.3390/antiox8100423
Abstract: Indirubin-3′-monoxime (I3M) exhibits anti-proliferative activity in various cancer cells; however, its anti-cancer mechanism remains incompletely elucidated. This study revealed that I3M promotes the expression of death receptor 5 (DR5) and tumor necrosis factor (TNF)-related apoptosis-inducing… read more here.
Keywords: apoptosis; hct116 p53; p53 cells; expression ... See more keywords
Simvastatin enhances the radiosensitivity of p53‑deficient cells via inhibition of mouse double minute 2 homolog.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of oncology"
DOI: 10.3892/ijo.2017.4192
Abstract: Simvastatin exhibits anticancer activities, but its molecular mechanisms and radiosensitizing effects relative to p53 status remain unclear. In this study, we investigated whether the combination of simvastatin and ionizing radiation (IR) would enhance the antitumor… read more here.
Keywords: simvastatin; hct116 p53; p53 cells; p53 deficient ... See more keywords