p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
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DOI: 10.1016/j.cell.2020.12.025
Abstract: The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We developed a platform to interrogate the chromatin accessibility landscape and transcriptional… read more here.
Keywords: p53 central; neurodegeneration; c9orf72; p53 ... See more keywords