p53 deficiency promotes bone regeneration by functional regulation of mesenchymal stromal cells and osteoblasts
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-022-01314-w
Abstract: The detailed mechanism of the process during bone healing of drill-hole injury has been elucidated, but a crucial factor in regulating drill-hole healing has not been identified. The transcription factor p53 suppresses osteoblast differentiation through… read more here.
Keywords: drill hole; mscs osteoblasts; p53 deficiency; bone ... See more keywords
ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness
Sign Up to like & getrecommendations! Published in 2022 at "EMBO reports"
DOI: 10.15252/embr.202154042
Abstract: Aberrant activation of the hypoxia‐inducible transcription factor HIF‐1 and dysfunction of the tumor suppressor p53 have been reported to induce malignant phenotypes and therapy resistance of cancers. However, their mechanistic and functional relationship remains largely… read more here.
Keywords: hypoxia signaling; p53 deficiency; p53; zbtb2 ... See more keywords
P53 Deficiency Accelerate Esophageal Epithelium Intestinal Metaplasia Malignancy
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11030882
Abstract: Barrett’s esophagus (BE) is a precancerous lesion of esophageal adenocarcinoma (EAC). It is a pathological change in which the squamous epithelium distal esophagus is replaced by columnar epithelium. Loss of P53 is involved in the… read more here.
Keywords: esophageal; p53 deficiency; expression; p53 ... See more keywords
p53 deficiency augments nucleolar instability after ionizing irradiation
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DOI: 10.3892/or.2019.7341
Abstract: Ribosomes are important cellular components that maintain cellular homeostasis through overall protein synthesis. The nucleolus is a prominent subnuclear structure that contains ribosomal DNA (rDNA) encoding ribosomal RNA (rRNA), an essential component of ribosomes. Despite… read more here.
Keywords: dna damage; p53 deficiency; deficiency; nucleolar fragmentation ... See more keywords
CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.72365
Abstract: Background: p53 deficiency is a key causal factor for tumor development and progression. p53 acts in this process through, at least in part, cooperation with YAP1 but the underlying molecular mechanism is incompletely understood. In… read more here.
Keywords: p53 deficiency; sarcoma; progression; clp36 ... See more keywords