A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109648
Abstract: Allium chinense is a vegetable with nutrition and unique flavor, and it is used as traditional Chinese medicine. We previously reported that the active compound A-24 induces apoptosis and autophagy in p53 wild-type gastric cancer… read more here.
Keywords: gastric cancer; p53; p53 deficient; cancer cells ... See more keywords
6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.477
Abstract: The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4) controls metabolic flux through allosteric regulation of glycolysis. Here we show that p53 regulates the expression of PFKFB4 and that p53-deficient cancer cells are highly dependent on the function of… read more here.
Keywords: deficient cancer; pfkfb4; cancer cells; cancer ... See more keywords
Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma
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DOI: 10.1038/s41388-021-02120-w
Abstract: Osteosarcoma (OS) in human patients is characterized by genetic alteration of TP53. Osteoprogenitor-specific p53-deleted mice (OS mice) have been widely used to study the process of osteosarcomagenesis. However, the molecular mechanisms responsible for the development… read more here.
Keywords: p53 deficient; p53; oncogenic myc; runx3 ... See more keywords
Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05805-1
Abstract: There are considerable challenges in directly targeting the mutant p53 protein, given the large heterogeneity of p53 mutations in the clinic. An alternative approach is to exploit the altered fitness of cells imposed by loss-of-wild-type… read more here.
Keywords: mitochondrial uncoupling; type p53; mutant p53; p53 deficient ... See more keywords
Abstract 3397: Evaluation of a novel two-drug combination strategy for p53-deficient colorectal and pancreatic cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3397
Abstract: Colorectal Cancer (CRC) and Pancreatic Ductal Adenocarcinoma (PDAC) are the most lethal cancers worldwide. Despite initial response to standard-of-care therapy, a significant proportion of CRC/PDAC cancers relapse and progress to metastatic disease with poor overall… read more here.
Keywords: combination; p53; p53 deficient; drug ... See more keywords
Effects of methotrexate exposure on medaka (Oryzias latipes) testes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Toxicologic Pathology"
DOI: 10.1293/tox.2017-0029
Abstract: For the purpose of clarifying the histopathological effects of methotrexate (MTX) on medaka testes, wild-type and homogenic p53-deficient male medaka at 4 to 6 months post-hatching were exposed to 0.25 mg/ml of MTX for 96… read more here.
Keywords: homogenic p53; medaka; p53 deficient; spermatogonia spermatocytes ... See more keywords
Delay in development and behavioural abnormalities in the absence of p53 in zebrafish
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DOI: 10.1371/journal.pone.0220069
Abstract: p53 is well-known for its tumour-suppressive activity. However, in the past decade it became clear that p53 is also involved in other processes including stem cell proliferation, differentiation and animal development. To investigate the role… read more here.
Keywords: p53 zebrafish; embryos; absence p53; p53 deficient ... See more keywords
Simvastatin enhances the radiosensitivity of p53‑deficient cells via inhibition of mouse double minute 2 homolog.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of oncology"
DOI: 10.3892/ijo.2017.4192
Abstract: Simvastatin exhibits anticancer activities, but its molecular mechanisms and radiosensitizing effects relative to p53 status remain unclear. In this study, we investigated whether the combination of simvastatin and ionizing radiation (IR) would enhance the antitumor… read more here.
Keywords: simvastatin; hct116 p53; p53 cells; p53 deficient ... See more keywords
DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53-deficient pancreatic cancer cells
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DOI: 10.3892/mmr.2017.7923
Abstract: The aberrant expression of DNA methyltransferases (DNMTs) has been considered to be associated with pancreatic carcinogenesis and progression. DNMT3a is widely involved in cell proliferation and cell cycle progression in pancreatic ductal adenocarcinoma (PDAC) cells.… read more here.
Keywords: gem; chemosensitivity; chemosensitivity gemcitabine; p53 deficient ... See more keywords
CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.72365
Abstract: Background: p53 deficiency is a key causal factor for tumor development and progression. p53 acts in this process through, at least in part, cooperation with YAP1 but the underlying molecular mechanism is incompletely understood. In… read more here.
Keywords: p53 deficiency; sarcoma; progression; clp36 ... See more keywords