Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173575
Abstract: MS-275 (Entinostat), is an oral histone deacetylase (HDAC) inhibitor with a high specificity for class 1 HDACs. As single agent, MS-275 exerts only modest antitumor activity against most solid malignancies. The use of MS-275 in… read more here.
Keywords: bax p53; histone deacetylase; antitumor effects; tetrandrine ... See more keywords
Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Nutrition and cancer"
DOI: 10.1080/01635581.2021.1903947
Abstract: Although a dietary phytochemical luteolin has been shown to regulate various anticancer mechanisms, a role of luteolin in autophagy regulation is mostly unidentified. Here, we investigated whether luteolin exhibits its anticancer effects by induction of… read more here.
Keywords: colon; colon cancer; p53 dependent; cancer cells ... See more keywords
7-hydroxyfrullanolide, isolated from Sphaeranthus indicus, inhibits colorectal cancer cell growth by p53 dependent and independent mechanism.
Sign Up to like & getrecommendations! Published in 2018 at "Carcinogenesis"
DOI: 10.1093/carcin/bgy176
Abstract: Sphaeranthus indicus Linn. is commonly used in Indian traditional medicine for management of multiple pathological conditions. However, there are limited studies on anti-cancer activity of this plant and its underlying molecular mechanisms. Here, we isolated… read more here.
Keywords: p53 dependent; cancer cell; cancer; p53 ... See more keywords
Abstract B044: Novel compounds suppressing p53-dependent growth of tumor cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b044
Abstract: Background: p53, a tumor suppressor gene, is required for cell cycle checkpoint signaling pathways and induction of apoptosis. In cell growth conditions, Mdm2, a ubiquitin E3 ligase, binds and ubiquitinates p53 and induces p53 degradation… read more here.
Keywords: cell; p53 dependent; cancer; p53 ... See more keywords
ISG20L1 acts as a co-activator of DAPK1 in the activation of p53 dependent cell death pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260915
Abstract: Our previous studies reveal that GADD45α is a liable proapoptotic protein, which undergoes MDM2 dependent constitutive ubiquitination and degradation in resting cancer cells. Under chemotherapeutic agents (such as arsenite, 5-Fu, VP-16) exposure, DAPK1 functions as… read more here.
Keywords: cell death; cell; dependent cell; p53 dependent ... See more keywords
Mitochondrial ROS-Mediated Metabolic and Cytotoxic Effects of Isoproterenol on Cardiomyocytes Are p53-Dependent and Reversed by Curcumin
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27041346
Abstract: Acute β-adrenergic stimulation contributes to heart failure. Here, we investigated the role of p53 in isoproterenol (ISO)-mediated metabolic and oxidative stress effects on cardiomyocytes and explored the direct protective effects offered by the antioxidant nutraceutical… read more here.
Keywords: mediated metabolic; mitochondrial ros; survival; curcumin ... See more keywords