Abstract 3536: SENP1 is a p53 deSUMOylating enzyme and its depletion induces p53 activity
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DOI: 10.1158/1538-7445.am2018-3536
Abstract: SUMOylation plays important roles in diverse cellular processes by regulating protein-protein interaction, protein localization, trafficking, stability and activity. p53 can by SUMOyalted at lysine (K) 384. Yet, how SUMOylation regulates p53 activity remain unclear. SUMOylation… read more here.
Keywords: desumoylating enzyme; p53 activity; p53 desumoylating; depletion ... See more keywords