The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.10.002
Abstract: In this study, we outline a regulatory network that involves the p53 tumor suppressor family and the Wnt pathway acting together with the TGF-β pathway in mesendodermal differentiation of mouse and human embryonic stem cells.… read more here.
Keywords: mesendodermal differentiation; family; differentiation; p53 family ... See more keywords
The p53 family reaches the final frontier: the variegated regulation of the dark matter of the genome by the p53 family in cancer
Sign Up to like & getrecommendations! Published in 2020 at "RNA Biology"
DOI: 10.1080/15476286.2019.1710054
Abstract: ABSTRACT The tumour suppressor p53 and its paralogues, p63 and p73, are essential to maintain cellular homoeostasis and the integrity of the cell’s genetic material, thus meriting the title of ‘guardians of the genome’. The… read more here.
Keywords: p53; genome p53; dark matter; p53 family ... See more keywords
Isoforms of the p53 Family and Gastric Cancer: A Ménage à Trois for an Unfinished Affair
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DOI: 10.3390/cancers13040916
Abstract: Simple Summary The p53 family is a complex family of transcription factors with different cellular functions that are involved in several physiological processes. A massive amount of data has been accumulated on their critical role… read more here.
Keywords: family gastric; gastric cancer; family; role ... See more keywords
Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness
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DOI: 10.3390/cancers13205231
Abstract: Simple Summary TP53 is one of the most important tumor suppressor genes, which has been found to be mutated in more than half of human cancers and is considered the “Guardian of the genome”. However,… read more here.
Keywords: melanoma; family isoforms; shorter p53; expression ... See more keywords
The p53 Family Members p63 and p73 Roles in the Metastatic Dissemination: Interactions with microRNAs and TGFβ Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14235948
Abstract: Simple Summary The p53 protein family is a class of proteins successively known to be the guardians of the genome, but also depending on the different isoforms have pro-tumoral and pro-metastatic potential. This dual potential… read more here.
Keywords: family; family members; metastatic spread; p53 family ... See more keywords