The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2017_5
Abstract: While tumors are very heterogeneous in their origins, mutations in the p53 gene and inactivation of p53 gene functions are the most common feature that predispose to the formation of cancers in humans. Inherited p53… read more here.
Keywords: inherited mutations; p53 gene; mutations p53; p53 ... See more keywords
Computational design of small interfering RNAs and small hairpin RNAs to silence mutated P53 gene expressions
Sign Up to like & getrecommendations! Published in 2018 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2018.04.004
Abstract: Abstract RNA silencing is a novel gene regulatory mechanism that confines the transcript level by either preventing translation or by the initiation of particular RNA degradation. Small interfering RNAs are regularly represented as the exogenously… read more here.
Keywords: small interfering; p53 gene; small hairpin; interfering rnas ... See more keywords
p53 Gene Mutation in Blood of Zebu Cattle with Squamous Cell Carcinoma of the Horn.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of comparative pathology"
DOI: 10.1016/j.jcpa.2020.09.018
Abstract: Horn cancer is one of the most important diseases in Zebu castrated male cattle. The objective of this study was to investigate the presence of p53 gene mutation in the blood of affected cattle and… read more here.
Keywords: gene mutation; p53 gene; blood; mutation ... See more keywords
Ultrasensitive electrochemiluminescence detection of p53 gene by a novel cloth-based microfluidic biosensor with luminol-gold nanoparticles and hybridization chain reaction amplification
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Luminescence"
DOI: 10.1016/j.jlumin.2020.117485
Abstract: Abstract A dual-signal-amplified cloth-based ECL biosensor has been firstly explored to detect p53 gene, where the luminol functionalized gold nanoparticles (Lu-AuNPs) are used for probe labels and signal amplification, and the hybridization chain reaction (HCR)… read more here.
Keywords: detection; gold nanoparticles; cloth based; p53 gene ... See more keywords
Ratiometric electrochemical biosensor for ultrasensitive and highly selective detection of p53 gene based on nicking endonuclease-assisted target recycling and rolling circle amplification
Sign Up to like & getrecommendations! Published in 2021 at "Microchemical Journal"
DOI: 10.1016/j.microc.2021.106461
Abstract: Abstract Tumor suppressor p53 gene is one vital anticancer gene that plays critical role in the prevention, diagnosis, and prognosis evaluation of cancers. Specific recognition and sensitive detection of p53 gene is important for early… read more here.
Keywords: p53 gene; nicking endonuclease; gene; biosensor ... See more keywords
Inhibitory effect of wild-type P53 gene transfer on graft coronary artery disease.
Sign Up to like & getrecommendations! Published in 2018 at "Transplant immunology"
DOI: 10.1016/j.trim.2018.02.004
Abstract: OBJECTIVE The aim of the present study was to investigate the inhibitory effect of wild-type P53 gene transfer on graft coronary artery disease (GCAD) after heart transplantation and the underlying mechanisms. METHODS A rat model… read more here.
Keywords: p53; p53 gene; wild type; coronary artery ... See more keywords
Exploring the binding mechanism of saccharin and sodium saccharin to promoter of human p53 gene by theoretical and experimental methods
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1582438
Abstract: Abstract In the past few decades, extensive discussions have been on the impact of artificial sweeteners on the risk of cancer. The present study aimed to evaluate the interaction of saccharin (SA) and sodium saccharin… read more here.
Keywords: p53 gene; promoter human; human p53; promoter ... See more keywords
Ameliorative Effects of Aspergillus awamori against the Initiation of Hepatocarcinogenesis Induced by Diethylnitrosamine in a Rat Model: Regulation of Cyp19 and p53 Gene Expression
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10060922
Abstract: Hepatocellular carcinoma (HCC) is the most common cancer in humans. Despite advances in its treatment, liver cancer remains one of the most difficult cancers to treat. This study aimed to investigate the ameliorative action and… read more here.
Keywords: initiation; aspergillus awamori; gene expression; p53 gene ... See more keywords
Determination of expression profile of p53 gene in different grades of breast cancer tissues by real time PCR
Sign Up to like & getrecommendations! Published in 2020 at "African Health Sciences"
DOI: 10.4314/ahs.v20i3.32
Abstract: Background Pakistan has a high incidence of breast cancer in Asia, where annually 16,232 deaths are reported. There are many exogenous and endogenous risk factors that affect the tumor suppressor genes and oncogenes. The p53… read more here.
Keywords: p53 gene; breast cancer; grades breast; expression ... See more keywords