Mdm4 supports DNA replication in a p53-independent fashion
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1325-1
Abstract: The Mdm4 (alias MdmX) oncoprotein, like its paralogue and interaction partner Mdm2, antagonizes the tumor suppressor p53. p53-independent roles of the Mdm proteins are emerging, and we have reported the ability of Mdm2 to modify… read more here.
Keywords: mdm4; dna replication; replication; p53 independent ... See more keywords
C2orf40 inhibits hepatocellular carcinoma through UBR5-dependent or p53-independent mechanisms.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of gastroenterology and hepatology"
DOI: 10.1111/jgh.15441
Abstract: BACKGROUND Hepatocellular carcinoma (HCC) urgently needs a marker for early diagnosis and targeted treatment. C2orf40 has been identified as a tumor suppressor gene in many cancers. However, the precise role and regulatory mechanism by C2orf40… read more here.
Keywords: hepatocellular carcinoma; dependent p53; c2orf40; p53 independent ... See more keywords
Lnc956 regulates mouse embryonic stem cell differentiation in response to DNA damage in a p53-independent pathway
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade9742
Abstract: Maintaining genomic stability is crucial for embryonic stem cells (ESCs). ESCs with unrepaired DNA damage are eliminated through differentiation and apoptosis. To date, only tumor suppressor p53 is known to be implicated in this quality… read more here.
Keywords: damage; embryonic stem; dna damage; p53 independent ... See more keywords
Abstract 2321: Molecular crosstalk between ferroptosis and apoptosis: Emerging role of ER stress-induced p53-independent PUMA expression
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2321
Abstract: Ferroptosis is a type of programmed cell death that depends on iron and is characterized by the accumulation of lipid peroxides. In the present study, we investigated the nature of the interplay between ferroptosis and… read more here.
Keywords: apoptosis; p53 independent; puma expression; ferroptosis ... See more keywords
Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13092115
Abstract: Simple Summary Chemotherapy is a commonly applied anticancer treatment, however therapy-induced senescent growth arrest has been associated with aggressive disease recurrence. The p21 protein, encoded by CDKN1A, plays a vital role in the induction of… read more here.
Keywords: p53 independent; senescence; p21; znf84 ... See more keywords
Novel focal adhesion kinase 1 inhibitor sensitizes lung cancer cells to radiation in a p53-independent manner.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oncology"
DOI: 10.3892/ijo.2017.4141
Abstract: Focal adhesion kinase 1 (FAK1) is known to promote tumor progression and metastasis by controlling cell movement, invasion, survival and the epithelial-to-mesenchymal transition in the tumor microenvironment. As recent reports imply that FAK1 is highly… read more here.
Keywords: independent manner; p53 independent; cancer; p53 ... See more keywords