The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2017.01.018
Abstract: The p53 tumour suppressor is a transcription factor that can increase the expression of mRNAs and microRNAs (miRNAs). HT29-tsp53 cells expressing a temperature sensitive variant of p53 have provided a useful model to rapidly and… read more here.
Keywords: p53 induced; induced mirnas; expression; p53 responsive ... See more keywords
CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.
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DOI: 10.1158/2159-8290.cd-17-0912
Abstract: Tumor formation is a multistep process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6 contributes to tumor formation by regulating transcriptional responses in a… read more here.
Keywords: cdk6 kinase; antagonizes p53; p53 induced; cdk6 antagonizes ... See more keywords
Role of wild-type p53-induced phosphatase 1 in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.6685
Abstract: Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response… read more here.
Keywords: p53 induced; type p53; role; cancer ... See more keywords