Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening
Sign Up to like & getrecommendations! Published in 2018 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s182444
Abstract: Background The tumor suppressor protein p53 plays an important role in preventing tumor formation and progression through its involvement in cell division control and initiation of apoptosis. Mdm2 protein controls the activity of p53 protein… read more here.
Keywords: protein; inhibitors mdm2; p53 interaction; mdm2 p53 ... See more keywords
Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666221114103924
Abstract: Discovery of MDM2 and MDM2-p53 interaction inhibitors changed the direction of anticancer research as it is involved in about 50% of cancer cases globally. Not only the inhibition of MDM2 but also its interaction with… read more here.
Keywords: p53 interaction; mdm2 p53; mdm2 mdm2; mdm2 ... See more keywords