Targeting Cellular Senescence in Cancer and Aging: Roles of p53 and its Isoforms.
Sign Up to like & getrecommendations! Published in 2020 at "Carcinogenesis"
DOI: 10.1093/carcin/bgaa071
Abstract: Cellular senescence and the associated secretory phenotype (SASP) promote disease in the aged population. Targeting senescent cells by means of removal, modulation of SASP, or through cellular reprogramming, represents a novel therapeutic avenue for treating… read more here.
Keywords: senescence; p53 isoforms; targeting cellular; cellular senescence ... See more keywords
The Elephant Evolved p53 Isoforms that Escape MDM2-Mediated Repression and Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac149
Abstract: Abstract The p53 tumor suppressor is a transcription factor with roles in cell development, apoptosis, oncogenesis, aging, and homeostasis in response to stresses and infections. p53 is tightly regulated by the MDM2 E3 ubiquitin ligase.… read more here.
Keywords: mdm2; p53 isoforms; cell signaling; p53 ... See more keywords
The Balance between p53 Isoforms Modulates the Efficiency of HIV-1 Infection in Macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.01188-21
Abstract: As of today, HIV-1 infection is still considered a global pandemic without a functional cure, partly because of the presence of stable viral reservoirs. Macrophages constitute one of these cell reservoirs, contributing to the viral… read more here.
Keywords: p53; role; hiv infection; p53 isoforms ... See more keywords
p53 and Its Isoforms in Renal Cell Carcinoma—Do They Matter?
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10061330
Abstract: p53 is a transcription al factor responsible for the maintenance of cellular homeostasis. It has been shown that more than 50% of tumors are connected with mutations in the Tp53 gene. These mutations cause a… read more here.
Keywords: renal cell; cell carcinoma; p53; p53 isoforms ... See more keywords
p53 Isoforms and Their Implications in Cancer
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DOI: 10.3390/cancers10090288
Abstract: In this review we focus on the major isoforms of the tumor-suppressor protein p53, dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the DNA binding domain, have been regarded… read more here.
Keywords: implications cancer; isoforms implications; p53 isoforms; dna binding ... See more keywords
p53 Isoforms as Cancer Biomarkers and Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133145
Abstract: Simple Summary The well-known tumor suppressor protein p53 plays important roles in tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 activity has been a potent strategy for cancer treatment. Accumulating evidences… read more here.
Keywords: p53 isoforms; isoforms cancer; p53; cancer biomarkers ... See more keywords
p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20236023
Abstract: Cellular senescence, a term originally used to define the characteristics of normal human fibroblasts that reached their replicative limit, is an important factor for ageing, age-related diseases including cancer, and cell reprogramming. These outcomes are… read more here.
Keywords: age related; senescence ageing; senescence; p53 isoforms ... See more keywords
Cytoplasmic p53β Isoforms Are Associated with Worse Disease-Free Survival in Breast Cancer
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DOI: 10.3390/ijms23126670
Abstract: TP53 mutations are associated with tumour progression, resistance to therapy and poor prognosis. However, in breast cancer, TP53′s overall mutation frequency is lower than expected (~25%), suggesting that other mechanisms may be responsible for the… read more here.
Keywords: survival breast; p53 isoforms; breast cancer; associated worse ... See more keywords