Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities.
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DOI: 10.1158/0008-5472.can-22-1577
Abstract: Malignant gliomas such as glioblastoma are highly heterogeneous with distinct cells of origin and varied genetic alterations. It remains elusive whether the specific states of neural cell lineages are differentially susceptible to distinct genetic alterations… read more here.
Keywords: intermediate lineage; loss induced; pten p53; p53 loss ... See more keywords
Abstract NG02: Ordered and selective patterns of cancer genome evolution revealed by lineage tracing of sporadic p53 loss
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DOI: 10.1158/1538-7445.am2023-ng02
Abstract: Inactivation of the tumor suppressor p53 is associated with molecular features such as genomic instability, polyploidy, and the emergence of heterogeneous tumors that acquire diverse copy number alterations (CNAs). Clinically, p53 loss is associated with… read more here.
Keywords: lineage tracing; cancer; p53; p53 loss ... See more keywords