Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.09.023
Abstract: Despite being the subject of extensive research and clinical trials, neuroblastoma remains a major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard that protects cells against genome instability and malignant transformation.… read more here.
Keywords: p53; p53 mdm2; mdm2 pathway; pathway neuroblastoma ... See more keywords
TPGS-mediated one-pot synthesis, XRD structural analysis, antimicrobial evaluation and molecular docking of novel heterocycles as potential inhibitors of p53-MDM2 protein
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.127252
Abstract: Abstract Novel heterocyclic bioactive small molecules bearing thioether moiety, fluorine containing dihydro pyridine and dihydro pyran were synthesized and characterized using spectroscopic methods (FT-IR, 1H, 13C and 19F NMR), LC-MS and SC-XRD. The reaction conducted… read more here.
Keywords: tpgs mediated; mediated one; one pot; p53 mdm2 ... See more keywords
Free Energy Profile and Kinetics of Coupled Folding and Binding of the Intrinsically Disordered Protein p53 with MDM2
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00920
Abstract: Intrinsically disordered proteins (IDPs) exert their functions by binding to partner proteins via a complex process that includes coupled folding and binding. Motivated by that inhibiting the binding of the IDP p53 to its partner… read more here.
Keywords: folding binding; coupled folding; process; p53 ... See more keywords
α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.9b00993
Abstract: The use of peptidomimetic scaffolds is a promising strategy for the inhibition of protein–protein interactions (PPIs). Herein, we demonstrate that sulfono-γ-AApeptides can be rationally designed to mimic the p53 α-helix and inhibit p53–MDM2 PPIs. The… read more here.
Keywords: protein; protein interactions; protein protein; sulfono aapeptides ... See more keywords
Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00988
Abstract: Peptides are being developed as targeted anticancer drugs to modulate cytosolic protein-protein interactions involved in cancer progression. However, their use as therapeutics is often limited by their low cell membrane permeation and/or inability to reach… read more here.
Keywords: cancer; cell; p53 mdm2; angler peptides ... See more keywords
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.9b03459
Abstract: The Sondheimer dialkyne reagent has previously been employed in strain-promoted double-click cycloadditions with bis-azide peptides to generate stapled peptide inhibitors of protein-protein interactions. The substituted variants of the Sondheimer dialkyne can be used to generate… read more here.
Keywords: sondheimer dialkyne; strain promoted; stapled peptide; p53 mdm2 ... See more keywords
Relevance of the p53–MDM2 axis to aging
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.187
Abstract: In response to varying stress signals, the p53 tumor suppressor is able to promote repair, survival, or elimination of damaged cells – processes that have great relevance to organismal aging. Although the link between p53… read more here.
Keywords: p53; p53 mdm2; mdm2 axis; relevance p53 ... See more keywords
Oscillatory Dynamics of p53-Mdm2 Circuit in Response to DNA Damage Caused by Ionizing Radiation
Sign Up to like & getrecommendations! Published in 2020 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2019.2899574
Abstract: Although the dynamical behavior of the p53-Mdm2 loop has been extensively studied, the understanding of the mechanism underlying the regulation of this pathway still remains limited. Herein, we developed an integrated model with five basic… read more here.
Keywords: ionizing radiation; p53 mdm2; level; p53 ... See more keywords
The role of p53‐MDM2 signaling in missed abortion and possible pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15385
Abstract: Missed abortion is one of the common obstetrical and gynecological complications, angiogenesis is the most important factor in fetal and placental development. However, the definite etiology and pathogenesis are not fully understood. read more here.
Keywords: abortion; mdm2 signaling; role p53; p53 mdm2 ... See more keywords
Theoretical study on the oscillation mechanism of p53-Mdm2 network
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Biomathematics"
DOI: 10.1142/s1793524518501127
Abstract: In this paper, a delayed mathematical model was developed based on experimental data to understand how the time delays required for transcription and translation in Mdm2 gene expression affect the kinetic behavior of the p53-Mdm2… read more here.
Keywords: time; model; time delays; mdm2 network ... See more keywords
Correlation between p53 and Mdm2 expression with histopathological parameters in cattle squamous cell carcinomas
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary World"
DOI: 10.14202/vetworld.2022.10-15
Abstract: Abstract Background and Aim: Squamous cell carcinoma (SCC) is the most common form of carcinoma in cattle. Histopathological grading systems have been utilized over several decades for estimating the malignancy of cattle SCCs. This study… read more here.
Keywords: expression; p53 mdm2; mdm2 expression; p53 ... See more keywords