The small molecule AU14022 promotes colorectal cancer cell death via p53‐mediated G2/M‐phase arrest and mitochondria‐mediated apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26234
Abstract: The p53 tumor suppressor plays critical roles in cell cycle regulation and apoptotic cell death, with its activation capable of sensitizing cancer cells to radiotherapy or chemotherapy. To identify small molecules that induce apoptosis via… read more here.
Keywords: p53 mediated; treatment; au14022; cancer ... See more keywords
Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Virologica Sinica"
DOI: 10.1007/s12250-021-00422-7
Abstract: Zika virus (ZIKV) infection could disrupt neurogenesis and cause microcephaly in neonates by targeting neural progenitor cells (NPCs). The tumor suppressor p53-mediated cell cycle arrest and apoptotic cell death have been suggested to be activated… read more here.
Keywords: zikv ns5; protein; p53 mediated; apoptosis ... See more keywords
Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.06.012
Abstract: Genome integrity in primordial germ cells (PGCs) is a prerequisite for fertility and species maintenance. In C. elegans, PGCs require global-genome nucleotide excision repair (GG-NER) to remove UV-induced DNA lesions. Failure to remove the lesions leads… read more here.
Keywords: cep p53; dna damage; p53 mediated; mediated dna ... See more keywords
Deconstructing networks of p53-mediated tumor suppression in vivo
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DOI: 10.1038/cdd.2017.171
Abstract: The transcription factor p53 is a vital tumor suppressor. Upon activation by diverse stresses including oncogene activation, DNA damage, hypoxia and nutrient deprivation, p53 activates a panoply of target genes and orchestrates numerous downstream responses… read more here.
Keywords: mediated tumor; p53 mediated; tumor suppression; p53 ... See more keywords
ALOX12 is required for p53-mediated tumor suppression through a distinct ferroptosis pathway
Sign Up to like & getrecommendations! Published in 2019 at "Nature cell biology"
DOI: 10.1038/s41556-019-0305-6
Abstract: It is well established that ferroptosis is primarily controlled by glutathione peroxidase 4 (GPX4). Surprisingly, we observed that p53 activation modulates ferroptotic responses without apparent effects on GPX4 function. Instead, ALOX12 inactivation diminishes p53-mediated ferroptosis… read more here.
Keywords: alox12; suppression; ferroptosis pathway; p53 mediated ... See more keywords
p53-mediated metabolic response to low doses of ionizing radiation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2142983
Abstract: Abstract Purpose Unlike treatment with high doses of radiation that causes considerable DNA damage resulting in injury and p53 activation, exposure of cells or whole animals to low doses of radiation (LDR, ∼10cGy) can induce… read more here.
Keywords: response; ldr; p53; radiation ... See more keywords
An African-specific variant of TP53 reveals PADI4 as a regulator of p53-mediated tumor suppression.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-22-1315
Abstract: TP53 is the most frequently mutated gene in cancer, yet key target genes for p53-mediated tumor suppression remain unidentified. Here, we characterize a rare, African-specific, germline variant of TP53 in the DNA binding domain, Tyr107His… read more here.
Keywords: tp53; p53; tumor suppression; tumor ... See more keywords
The Role of p53-Mediated Signaling in the Therapeutic Response of Colorectal Cancer to 9F, a Spermine-Modified Naphthalene Diimide Derivative
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12030528
Abstract: Colorectal cancer (CRC) is one of the most prevalent cancers due to its frequency and high rate of mortality. Polyamine-vectorized anticancer drugs possess multiple biological properties. Of these drugs, 9F has been shown to inhibit… read more here.
Keywords: signaling therapeutic; role p53; p53 mediated; colorectal cancer ... See more keywords