Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway
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DOI: 10.1038/s41388-019-1035-8
Abstract: The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as a metabolic regulator in the treatment of metabolic diseases; here, DCA was assayed to… read more here.
Keywords: mir 149; colorectal cancer; crc; p53 mir ... See more keywords
A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness
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DOI: 10.1038/s41418-018-0103-x
Abstract: Inactivation of p53 contributes significantly to the dismal prognosis of breast tumors, most notably triple-negative breast cancers (TNBCs). How the relief from p53 tumor suppressive functions results in tumor cell aggressive behavior is only partially… read more here.
Keywords: p53 mir; breast; axis; 30a zeb2 ... See more keywords