p53 mutants G245S and R337H associated with the Li-Fraumeni syndrome regulate distinct metabolic pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Biochimie"
DOI: 10.1016/j.biochi.2022.03.003
Abstract: Li-Fraumeni and Li-Fraumeni-like syndromes (LFS/LFL) are hereditary cancer predisposition disorders associated with germline mutations in the TP53 tumor suppressor gene. Here, we stably expressed LFS/LFL-associated p53 mutants R337H and G245S in p53-null H1299 cells to study… read more here.
Keywords: expression; p53 mutants; distinct metabolic; lfs lfl ... See more keywords
Virtual screening of p53 mutants reveals Y220S as an additional rescue drug target for PhiKan083 with higher binding characteristics
Sign Up to like & getrecommendations! Published in 2019 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2019.05.005
Abstract: Pharmacological intervention to reactivate p53 in human tumors holds great promise for cancer patients. A number of small molecules that reactivate p53 mutants that are either specific to certain mutation or more broadly on various… read more here.
Keywords: target; p53 mutants; drug; interaction ... See more keywords
HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.344
Abstract: Mutation of p53 is a frequent genetic lesion in pancreatic cancer being an unmet clinical challenge. Mutants of p53 have lost the tumour-suppressive functions of wild type p53. In addition, p53 mutants exert tumour-promoting functions,… read more here.
Keywords: p53; hdac1 hdac2; pancreatic cancer; p53 mutants ... See more keywords
Context is everything: extrinsic signalling and gain-of-function p53 mutants.
Sign Up to like & getrecommendations! Published in 2020 at "Cell death discovery"
DOI: 10.1038/s41420-020-0251-x
Abstract: The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants… read more here.
Keywords: p53; gain function; context everything; p53 mutants ... See more keywords
p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1808314115
Abstract: Significance Expression in cancer cells of novel proteins generated by mutations in the TP53 gene is an important prognostic factor; however, how p53 mutants promote cancer progression is largely unknown. Here, we describe a molecular… read more here.
Keywords: hif; extracellular matrix; p53 mutants; cancer ... See more keywords
Comprehensive omics studies of p53 mutants in human cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elac015
Abstract: The p53 is the master regulator of the cell known for regulating a large array of cellular processes. Inactivation of p53 by missense mutations is one of the leading causes of cancer. Some of these… read more here.
Keywords: studies p53; omics studies; p53 mutants; p53 ... See more keywords
p53 and its mutants on the slippery road from stemness to carcinogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Carcinogenesis"
DOI: 10.1093/carcin/bgw092
Abstract: Normal development, tissue homeostasis and regeneration following injury rely on the proper functions of wide repertoire of stem cells (SCs) persisting during embryonic period and throughout the adult life. Therefore, SCs employ robust mechanisms to… read more here.
Keywords: mutants slippery; p53 mutants; carcinogenesis p53; cancer ... See more keywords
Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3464
Abstract: Missense mutations in the DNA binding domain of p53 are characterized as structural or contact mutations based on their effect on the conformation of the protein. These mutations show gain-of-function activities, such as promoting increased… read more here.
Keywords: profiles underlie; p53 mutants; underlie osteosarcomagenesis; transcriptional profiles ... See more keywords
Regulation of miRNAs Expression by Mutant p53 Gain of Function in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.695723
Abstract: The p53 roles have been largely described; among them, cell proliferation and apoptosis control are some of the best studied and understood. Interestingly, the mutations on the six hotspot sites within the region that encodes… read more here.
Keywords: gain function; expression; regulation mirnas; p53 ... See more keywords
Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20235999
Abstract: Colorectal cancer (CRC) is a kind of solid tumor and the third most common cancer type in the world. It is a heterogeneous disease characterized by genetic and epigenetic aberrations. The TP53 mutation is the… read more here.
Keywords: solid tumors; colorectal cancer; p53 mutants; p53 ... See more keywords
Insights into Allosteric Mechanisms of the Lung-Enriched p53 Mutants V157F and R158L
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231710100
Abstract: Lung cancer is a leading fatal malignancy in humans. p53 mutants exhibit not only loss of tumor suppressor capability but also oncogenic gain-of-function, contributing to lung cancer initiation, progression and therapeutic resistance. Research shows that… read more here.
Keywords: insights allosteric; p53 mutants; lung; v157f r158l ... See more keywords