AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1301329
Abstract: ABSTRACT AZD1775 is a small molecule WEE1 inhibitor used in combination with DNA-damaging agents to cause premature mitosis and cell death in p53-mutated cancer cells. Here we sought to determine the mechanism of action of… read more here.
Keywords: dna breaks; cancer cells; p53 mutated; dna ... See more keywords
Abstract 6928: Combination treatment with cisplatin and PG3 for p53-mutated head & neck cancers
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DOI: 10.1158/1538-7445.am2025-6928
Abstract: More than 90% of head & neck (H&N) cancers are squamous cell carcinoma (HNSCC) that occur from the mucosal epithelial tissue of the oral cavity, oropharynx, and larynx. About 30∼40% of stage I or II… read more here.
Keywords: p53; combination treatment; cisplatin; p53 mutated ... See more keywords
Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition
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DOI: 10.1186/s12885-025-14361-z
Abstract: The human double minute 2 homolog hdm2, alias mdm2, is the main negative-regulator of the tumor suppressor p53. In that capacity, mdm2 is a promising but not yet utilized molecular target for the treatment of… read more here.
Keywords: mdm2; p53 wildtype; p53; cell ... See more keywords
Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells
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DOI: 10.3390/cancers10110396
Abstract: The protein p53 protects the organism against carcinogenic events by the induction of cell cycle arrest and DNA repair program upon DNA damage. Virtually all cancers inactivate p53 either by mutations/deletions of the TP53 gene… read more here.
Keywords: idasanutlin rg7388; generation p53; treatment; p53 mutated ... See more keywords