AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells
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DOI: 10.1080/15384101.2017.1301329
Abstract: ABSTRACT AZD1775 is a small molecule WEE1 inhibitor used in combination with DNA-damaging agents to cause premature mitosis and cell death in p53-mutated cancer cells. Here we sought to determine the mechanism of action of… read more here.
Keywords: dna breaks; cancer cells; p53 mutated; dna ... See more keywords
Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells
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DOI: 10.3390/cancers10110396
Abstract: The protein p53 protects the organism against carcinogenic events by the induction of cell cycle arrest and DNA repair program upon DNA damage. Virtually all cancers inactivate p53 either by mutations/deletions of the TP53 gene… read more here.
Keywords: idasanutlin rg7388; generation p53; treatment; p53 mutated ... See more keywords