Simulations reveal that different responses to cell crowding determine the expansion of p53 and Notch mutant clones in squamous epithelia
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DOI: 10.1098/rsif.2021.0607
Abstract: During ageing, normal epithelial tissues progressively accumulate clones carrying mutations that increase mutant cell fitness above that of wild-type cells. Such mutants spread widely through the tissues, yet despite this cellular homeostasis and functional integrity… read more here.
Keywords: mutant; cell crowding; p53; p53 notch ... See more keywords