SETD8C302R Mutation Revealed from Myofibroblastoma‐Discordant Monozygotic Twins Leads to p53/p21 Deficit and WEE1 Inhibitor Sensitivity
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.202001041
Abstract: Abstract High‐throughput gene sequencing has identified various genetic variants as the culprits for some common hereditary cancers. However, the heritability of a substantial proportion of cancers remains unexplained, which may result from rare deleterious mutations… read more here.
Keywords: p53 p21; myofibroblastoma; wee1 inhibitor; setd8c302r mutation ... See more keywords
The p53/p21/p16 and PI3K/Akt signaling pathways are involved in the ameliorative effects of maltol on D‐galactose‐induced liver and kidney aging and injury
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7142
Abstract: Successive evidence has established that maltol, a flavor‐enhancing agent, could provide resistance to oxidative stress‐induced tissue injury in various animal models though its benefits for aging‐induced liver and kidney injuries are still undetermined. In the… read more here.
Keywords: liver kidney; p53 p21; induced liver; p21 p16 ... See more keywords
Histone deacetylase inhibitor chidamide induces growth inhibition and apoptosis in NK/T lymphoma cells through ATM-Chk2-p53-p21 signalling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0552-y
Abstract: SummaryWe investigated the anti-tumour effects and the underlying molecular mechanisms of a new oral histone deacetylase inhibitor (HDACi), chidamide, in NK/T cell lymphoma (NKTCL), a rare and highly aggressive non-Hodgkin lymphoma with poor outcomes. SNT-8… read more here.
Keywords: p53 p21; chidamide; lymphoma; chk2 p53 ... See more keywords
Decline of p300 contributes to cell senescence and growth inhibition of hUC-MSCs through p53/p21 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.061
Abstract: Human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) in vitro expansion for long term may undergo epigenetic and genetic alterations that subsequently induce cellular senescence and associated growth inhibition. Increasing evidence implicated that aberrant histone acetylation modulates… read more here.
Keywords: p53 p21; huc mscs; senescence; inhibition ... See more keywords
Cell cycle regulation: p53-p21-RB signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00988-z
Abstract: The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both proteins play central roles in regulating the cell division cycle. RB forms… read more here.
Keywords: p53 p21; cell cycle; p53;
Melatonin protects against nonylphenol caused pancreatic β-cells damage through MDM2-P53-P21 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology research"
DOI: 10.1093/toxres/tfac016
Abstract: Nonylphenol (NP) is an endocrine disrupting chemical, which widely exists in environment and can result in multiple system dysfunction. Pancreas as one of the most important organs is sensitive to NP, while the detail toxic… read more here.
Keywords: dysfunction; p53 p21; mdm2 p53; p21 axis ... See more keywords
Aging Induced p53/p21 in Genioglossus Muscle Stem Cells and Enhanced Upper Airway Injury
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells International"
DOI: 10.1155/2020/8412598
Abstract: Aging of population brings related social problems, such as muscle attenuation and regeneration barriers with increased aging. Muscle repair and regeneration depend on muscle stem cells (MuSCs). Obstructive sleep apnea (OSA) rises in the aging… read more here.
Keywords: p53 p21; muscle; upper airway; hypoxia ... See more keywords
Bcl-2 Protein Targeting by the p53/p21 Complex-Response.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-3919
Abstract: We thank Hernandez Borrero and colleagues for their comments ([1][1]) on our article ([2][2]), especially their consideration of novel paradigm-shifting aspects. As they requested, we have presented coimmunoprecipitation data showing endogenous p53–p21 protein interaction in… read more here.
Keywords: p53 p21; bcl protein; protein targeting; p53 ... See more keywords
Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.210724
Abstract: ABSTRACT Heat shock transcription factor 1 (HSF1) regulates the expression of a wide array of genes, controls the expression of heat shock proteins (HSPs) as well as cell growth. Although acute depletion of HSF1 induces… read more here.
Keywords: p53 p21; p21 pathway; mdm2; senescence ... See more keywords
Inhibition of Proliferation and Induction of Apoptosis by Thymoquinone via Modulation of TGF Family, p53, p21 and Bcl-2α in Leukemic Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520617666170912133054
Abstract: INTRODUCTION Adult T-cell leukemia (ATL) is an aggressive form of malignancy caused by human T- cell lymphotropic virus 1 (HTLV-1). Currently, there is no effective treatment for ATL. Thymoquinone has been reported to have anti-cancer… read more here.
Keywords: p53 p21; apoptosis; induction; thymoquinone ... See more keywords
JNK inhibitor IX restrains pancreatic cancer through p53 and p21
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1006131
Abstract: Novel treatment options for pancreatic cancer are desperately needed. De-regulated kinases can be regularly detected in pancreatic cancer. Multiple pathway inhibitors were developed to exploit these features, among them selective inhibitors of the c-Jun N-terminal… read more here.
Keywords: pancreatic cancer; p53 p21; cancer; jnk inhibitor ... See more keywords