Protective effect of astaxanthin against contrast-induced acute kidney injury via SIRT1-p53 pathway in rats
Sign Up to like & getrecommendations! Published in 2018 at "International Urology and Nephrology"
DOI: 10.1007/s11255-018-2027-2
Abstract: PurposeThe present study was designed to further investigate the protective effect of astaxanthin (AST) on contrast-induced acute kidney injury (CI-AKI) in rats and the relationship between SIRT1-p53 pathway and astaxanthin.Methods40 adult male Sprague Dawley (SD)… read more here.
Keywords: protective effect; group; p53; sirt1 p53 ... See more keywords
Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cell"
DOI: 10.1016/j.molcel.2019.07.025
Abstract: Summary Long non-coding RNAs (lncRNAs) are key regulatory molecules, but unlike with other RNAs, the direct link between their tertiary structure motifs and their function has proven elusive. Here we report structural and functional studies… read more here.
Keywords: pseudoknots lncrna; meg3; conserved pseudoknots; stimulation ... See more keywords
Fenpropathrin Induces GLT-1 Ubiquitination and Increases IL-6 Secretion through the Mdm2-p53 Pathway.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00112
Abstract: Human exposure to fenpropathrin, a widely used pesticide, is linked to Parkinson's-like symptoms in the body. However, a specific pathogenic mechanism is still unclear. This study found that fenpropathrin increased the expression of murine double… read more here.
Keywords: mdm2; p53 pathway; secretion; p53 ... See more keywords
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-13911-x
Abstract: Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption and associated illnesses, yet its aging mechanisms remain unclear. Here, we show that aging-caused intestinal villus structural and functional decline is… read more here.
Keywords: p38 mapk; stem; mapk p53; p53 pathway ... See more keywords
Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120403119
Abstract: SignificanceVHL tumor suppressor gene inactivation is a hallmark of clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, and promotes tumor growth by stabilizing the hypoxia-inducible factor 2 (HIF2) transcription factor.… read more here.
Keywords: hif2 inhibitors; p53; p53 pathway; intact p53 ... See more keywords
Activation of P53 pathway contributes to Xenopus hybrid inviability.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2303698120
Abstract: Hybrid incompatibility as a kind of reproductive isolation contributes to speciation. The nucleocytoplasmic incompatibility between Xenopus tropicalis eggs and Xenopus laevis sperm (te×ls) leads to specific loss of paternal chromosomes 3L and 4L. The hybrids… read more here.
Keywords: contributes xenopus; pathway contributes; p53 pathway; p53 ... See more keywords
Increased miR‐34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS‐JNK‐p53 pathway in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "Aging Cell"
DOI: 10.1111/acel.13125
Abstract: Alzheimer's disease (AD) and cancer have inverse relationship in many aspects. Some tumor suppressors, including miR‐34c, are decreased in cancer but increased in AD. The upstream regulatory pathways and the downstream mechanisms of miR‐34c in… read more here.
Keywords: ros jnk; jnk p53; increased mir; p53 pathway ... See more keywords
PO-445 E7107 treatment results in aberrantly spliced transcripts and protein products of P53 pathway genes
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.468
Abstract: Introduction Recent studies indicate that E7107, a spliceosome inhibitor, causes altered splicing of key genes in CLL. We evaluated the effect of E7107 on cell viability and key proteins in the p53 pathway. Material and… read more here.
Keywords: cell lines; molecular weight; p21; cell ... See more keywords
Emerging Role of the p53 Pathway in Modulating Natural Killer Cell Mediated Immunity.
Sign Up to like & getrecommendations! Published in 2024 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-24-0325
Abstract: The p53 pathway plays an important role in role in cancer immunity. Mutation or downregulation of the proteins in the p53 pathway are prevalent in many cancers, contributing to tumor progression and immune dysregulation. Recent… read more here.
Keywords: p53 pathway; role; immunity; p53 ... See more keywords
Huashi Jiedu Decoction Enhances 5-Fluorouracil Efficacy in Gastric Cancer via miRNA-21-3p/p53 Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s513371
Abstract: Purpose To explore the mechanism of Huashi Jiedu Decoction (HJD) synergizing with 5-fluorouracil (5-Fu) in gastric cancer (GC) therapy. Methods MicroRNAs (miRNAs) and genes involved in HJD-mediated GC treatment were identified using ultra-high-performance liquid chromatography… read more here.
Keywords: p53 pathway; jiedu decoction; mirna p53; gastric cancer ... See more keywords
The p53 Pathway Related Genes Predict the Prognosis of Colon Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s346280
Abstract: Background Colon cancer is a common gastrointestinal malignancy. This study aimed to explore the relationship between p53 pathway-related genes and prognosis of colon cancer. Methods The mRNA datasets of colon cancer and adjacent tissues were… read more here.
Keywords: p53 pathway; pathway related; colon cancer; related genes ... See more keywords