Calculation of hot spots for protein–protein interaction in p53/PMI‐MDM2/MDMX complexes
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DOI: 10.1002/jcc.25592
Abstract: The recently developed MM/GBSA_IE method is applied to computing hot and warm spots in p53/PMI‐MDM2/MDMX protein–protein interaction systems. Comparison of the calculated hot (>2 kcal/mol) and warm spots (>1 kcal/mol) in P53 and PMI proteins… read more here.
Keywords: mdm2 mdmx; p53 pmi; mdmx;