Evaluation of P53 protein expression in gingival tissues of patients with chronic periodontitis by immunohistochemistry methods
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.668
Abstract: Periodontitis is one of the most important periodontal diseases that can be affected by many factors. Although the mechanism of periodontitis development is not yet fully understood, previous studies suggest that apoptosis may be one… read more here.
Keywords: patients chronic; chronic periodontitis; expression; periodontitis ... See more keywords
A comprehensive study of p53 protein
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30331
Abstract: The protein p53 has been extensively investigated since it was found 43 years ago and has become a “guardian of the genome” that regulates the division of cells by preventing the growth of cells and… read more here.
Keywords: study p53; p53; comprehensive study; p53 protein ... See more keywords
Thiostrepton degrades mutant p53 by eliciting an autophagic response in SW480 cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26601
Abstract: Mutations in p53 gene are one of the hallmarks of tumor development. Specific targeting of mutant p53 protein has a promising role in cancer therapeutics. Our preliminary observation showed destabilization of mutant p53 protein in… read more here.
Keywords: p53 protein; bag3; treatment; thiostrepton ... See more keywords
Potential of rescue and reactivation of tumor suppressor p53 for cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical Reviews"
DOI: 10.1007/s12551-021-00915-5
Abstract: The tumor suppressor protein p53, a transcription product of the anti-oncogene TP53 , is a critical factor in preventing cellular cancerization and killing cancer cells by inducing apoptosis. As a result, p53 is often referred… read more here.
Keywords: cancer; p53 protein; tumor suppressor; p53 ... See more keywords
Efficient intracellular delivery of p53 protein by engineered protein crystals restores tumor suppressing function in vivo.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120759
Abstract: Direct delivery of proteins into cells holds significant potential for basic research and drug development. However, the poor endosomal escape of conventional delivery strategies remains a challenge, thus limiting the clinical translation of many protein… read more here.
Keywords: p53 protein; delivery; function; p53 ... See more keywords
Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.09.027
Abstract: The members of the solute carrier (SLC) superfamily are vital membrane transporters in human cells. In the present study, we determine the expression and function of SLC5 family members in colorectal cancer (CRC). Expression analysis… read more here.
Keywords: p53 protein; colorectal cancer; expression; cancer ... See more keywords
Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14844
Abstract: TP53, a critical tumour suppressor gene, is mutated in over half of all cancers resulting in mutant-p53 protein accumulation and poor patient survival. Therapeutic strategies to target mutant-p53 cancers are urgently needed. We show that… read more here.
Keywords: p53 protein; system; mutant p53; glutathione axis ... See more keywords
Unprovoked Stabilization and Nuclear Accumulation of the Naked Mole-Rat p53 Protein
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64009-0
Abstract: The naked mole-rat is a subterranean rodent, approximately the size of a mouse, renowned for its exceptional longevity (>30 years) and remarkable resistance to cancer. To explore putative mechanisms underlying the cancer resistance of the… read more here.
Keywords: naked mole; p53 protein; mole rat;
P53 and taurine upregulated gene 1 promotes the repair of the DeoxyriboNucleic Acid damage induced by bupivacaine in murine primary sensory neurons
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2048985
Abstract: ABSTRACT The research aimed to explore the biological role of p53 protein and long non-coding RNA (lncRNA) taurine upregulated gene 1 (TUG1) in bupivacaine (bup)-induced neurotoxicity. Our work treated dorsal root ganglion (DRG) cells with… read more here.
Keywords: dna damage; murine; p53; p53 protein ... See more keywords
SMYD3 promotes epithelial ovarian cancer metastasis by down-regulating p53 protein stability and promoting p53 ubiquitination.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz078
Abstract: Epithelial ovarian cancer (EOC) has a very poor prognosis because of tumor invasiveness. Here, we reported that SMYD3 a lysine methyltransferase was frequently upregulated in EOC and associated with poor prognosis. A series of in… read more here.
Keywords: smyd3; epithelial ovarian; p53 protein; metastasis ... See more keywords
The many faces of p53: something for everyone
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz026
Abstract: The p53 gene, from discovery to classification: the first 10 years Forty years ago four research laboratories in London, Paris, New York/Bethesda, and Princeton uncovered the existence of the p53 protein (Deleo et al., 1979;… read more here.
Keywords: protein; p53 protein; tumor suppressor; antigen ... See more keywords