Encorafenib enhances TRAIL-induced apoptosis of colorectal cancer cells dependent on p53/PUMA signaling
Sign Up to like & getrecommendations! Published in 2020 at "Cytotechnology"
DOI: 10.1007/s10616-020-00442-3
Abstract: TRAIL has been demonstrated to play a critical role in the apoptosis of colorectal cancer (CRC) cells, but drug resistance markedly restricts its therapeutic effects. Objectives: This study aims to investigate whether encorafenib can enhance… read more here.
Keywords: trail; crc cells; trail induced; p53 puma ... See more keywords
Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2211775119
Abstract: Synthetic lethality is a powerful approach for targeting oncogenic drivers in cancer. Recent studies revealed that cancer cells with microsatellite instability (MSI) require Werner (WRN) helicase for survival; however, the underlying mechanism remains unclear. In… read more here.
Keywords: msi; helicase; p53; p53 puma ... See more keywords
Expressions of p53 and PUMA in fibroblasts of systemic sclerosis patients are normal at transcription level
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.12420
Abstract: Systemic sclerosis (SSc) fibroblasts show resistance apoptosis mechanisms, which enhances the fibrosis stage of the disease. Impaired function of p53 upregulated modulator of apoptosis (PUMA) has been related to deficits in p53‐dependant apoptosis pathway. This… read more here.
Keywords: puma fibroblasts; expressions p53; p53 puma; fibroblasts systemic ... See more keywords