IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma
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DOI: 10.1038/s41388-021-02111-x
Abstract: As the p53 tumor suppressor is rarely mutated in conjunctival melanoma (CM), we investigated its activation as a potential therapeutic strategy. Preventing p53/Mdm2 interaction by Nutlin-3, the prototypical Mdm2 antagonist, or via direct siRNA Mdm2… read more here.
Keywords: p53 reactivation; igf; conjunctival melanoma; p53 ... See more keywords