The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses.
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DOI: 10.1016/j.gene.2017.01.018
Abstract: The p53 tumour suppressor is a transcription factor that can increase the expression of mRNAs and microRNAs (miRNAs). HT29-tsp53 cells expressing a temperature sensitive variant of p53 have provided a useful model to rapidly and… read more here.
Keywords: p53 induced; induced mirnas; expression; p53 responsive ... See more keywords
Modeling amplified p53 responses under DNA-PK inhibition in DNA damage response
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DOI: 10.18632/oncotarget.15062
Abstract: During DNA double strand breaks (DSBs) repair, coordinated activation of phosphatidylinositol 3-kinase (PI3K)-like kinases can activate p53 signaling pathway. Recent findings have identified novel interplays among these kinases demonstrating amplified first p53 pulses under DNA-PK… read more here.
Keywords: amplified p53; inhibition; dna inhibition; p53 responses ... See more keywords