Genetic variants in p53 signaling pathway genes predict chemotherapy efficacy in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2215
Abstract: The murine double minute‐2 gene (MDM2) was originally identified as predicting chemotherapy efficacy. However, little is known regarding the association between single nucleotide polymorphisms (SNPs) in the p53 signaling pathway and prognosis/chemotherapy sensitivity in colorectal… read more here.
Keywords: chemotherapy; p53 signaling; colorectal cancer; signaling pathway ... See more keywords
Downregulation of microRNA‐23b protects against ischemia‐reperfusion injury via p53 signaling pathway by upregulating MDM4 in rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27748
Abstract: Total knee arthroplasty is a commonly performed safe procedure and typically executed in severe knee arthritis, but it also triggers ischemia‐reperfusion injury (IRI). More recently, microRNAs (miRs) have been reported to play a contributory role… read more here.
Keywords: p53 signaling; mdm4; mir 23b; signaling pathway ... See more keywords
The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-019-09462-y
Abstract: Bufalin is the primary component of the traditional Chinese medicine “Chan Su,” which has been widely used for cancer treatment at oncology clinics in certain countries. Evidence suggests that this compound possesses potent antitumor activities,… read more here.
Keywords: bufalin; p53 signaling; glioma; sensitivity ... See more keywords
Aflatoxin B1 interferes with embryonic liver development: involvement of p53 signaling and apoptosis in zebrafish.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152844
Abstract: Aflatoxin B1 (AFB1), a naturally occurring mycotoxin, is present in human placenta and cord blood. AFB1 at concentrations found in contaminated food commodities (0.25 and 0.5 μM) did not alter the spontaneous movement, heart rate, hatchability,… read more here.
Keywords: p53 signaling; embryonic liver; apoptosis; signaling apoptosis ... See more keywords
SKA1 is overexpressed in laryngocarcinoma and modulates cell growth via P53 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2145817
Abstract: ABSTRACT Laryngocarcinoma is one of the most frequent malignancies occurring in the head and neck. The roles of spindle- and kinetochore-associated complex 1 (SKA1) in the malignant progression of several cancers have already been discussed.… read more here.
Keywords: signaling pathway; growth; p53 signaling; p53 ... See more keywords
Bioinformatics analysis of key genes and pathways for hepatocellular carcinoma transformed from cirrhosis
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000006938
Abstract: Objective: We aimed to identify some pivotal genes and pathways for hepatocellular carcinoma (HCC) transformation from cirrhosis and explore potential targets for treatment of the disease. Methods: The GSE17548 microarray data were downloaded from Gene… read more here.
Keywords: transformed cirrhosis; hepatocellular carcinoma; pathways hepatocellular; genes pathways ... See more keywords
TRIM3 inhibits P53 signaling in breast cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Cell International"
DOI: 10.1186/s12935-020-01630-z
Abstract: Background Beast cancer is the most common women cancer worldwide, while two third of them are ER alpha positive breast cancer. Among the ER alpha positive breast cancer, about 80% are P53 wild type, indicating… read more here.
Keywords: used detect; p53 signaling; breast cancer; cancer ... See more keywords
Downregulation of GBAS regulates oral squamous cell carcinoma proliferation and apoptosis via the p53 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s207930
Abstract: Purpose: Oral squamous cell carcinoma (OSCC) is the most common and severe type of head and neck malignancy. The mechanisms by which OSCC arises depend on changes in a number of different factors and genes… read more here.
Keywords: p53 signaling; cell; gbas; proliferation apoptosis ... See more keywords
MiR-125b Improves acute myocardial infarction in rats by regulating P38/Sirtl/P53 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of biological regulators and homeostatic agents"
DOI: 10.23812/20-177-a
Abstract: The aim of this study was to investigate the differential expression of micro ribonucleic acid (miR)- 125b in acute myocardial infarction (AMI) cases, and to explore the mechanism by which it affects cardiac function. Sprague-Dawley… read more here.
Keywords: expression; acute myocardial; mir 125b; p53 signaling ... See more keywords
The Role of p53 Signaling in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13092125
Abstract: Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates diverse cellular responses to protect against cancer development. Deactivating p53 signaling either by altering p53 regulators or by p53 mutations occurs frequently… read more here.
Keywords: p53 signaling; colorectal cancer; cancer; p53 ... See more keywords
Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222111315
Abstract: Cancer is a major cause of death, affecting human life in both developed and developing countries. Numerous antitumor agents exist but their toxicity and low efficacy limits their utility. Furthermore, the complex pathophysiological mechanisms of… read more here.
Keywords: modulation; p53 signaling; signaling pathway; cancer ... See more keywords