Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53/SLC7A11-mediated ferroptosis
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147216
Abstract: Cerebral ischemia is the most common cause of hippocampal neuronal death and the most prevalent cause of stroke with high mortality rate. Ferroptosis has been suggested to affect the role of hippocampal neurons. This study… read more here.
Keywords: hippocampal neuronal; cerebral ischemia; neuronal death; p53 slc7a11 ... See more keywords
Astragaloside IV Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis via the p53/SLC7A11/GPX4 Axis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s572167
Abstract: Purpose Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage damage. Astragaloside IV (AS-IV), a cyclic triterpenoid saponin extracted from Astragalus membranaceus, exhibits antioxidant and cartilage-protective activities. However, its mechanism of action in… read more here.
Keywords: slc7a11 gpx4; p53 slc7a11; chondrocyte ferroptosis; ferroptosis ... See more keywords