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Published in 2022 at "Toxics"
DOI: 10.3390/toxics10050274
Abstract: Recent studies indicated renal toxicity and interstitial nephritis in patients receiving leflunomide (LEFN), but the exact mechanism is still unknown. The transforming growth factor β (TGFβ)/p53/Smad2/3 pathway crucially mediates renal fibrosis. We aimed to assess…
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Keywords:
smad2 signaling;
p53 smad2;
nephrotoxicity mice;
p53 ... See more keywords