A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
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DOI: 10.1038/s41467-018-03441-3
Abstract: The development of non-genotoxic therapies that activate wild-type p53 in tumors is of great interest since the discovery of p53 as a tumor suppressor. Here we report the identification of over 100 small-molecules activating p53… read more here.
Keywords: inhibitor; p53 synthesis; dhodh; p53 ... See more keywords