Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells
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DOI: 10.1038/s41598-017-11208-x
Abstract: Abstractp53 encodes a transcription factor that transactivates downstream target genes involved in tumour suppression. Although osteosarcoma frequently has p53 mutations, the role of p53 in osteosarcomagenesis is not fully understood. To explore p53-target genes comprehensively… read more here.
Keywords: p53 target; cd137l; target; immune response ... See more keywords
Preferential translation of p53 target genes
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DOI: 10.1080/15476286.2022.2048562
Abstract: ABSTRACT The transcription factor p53 exerts its tumour suppressive effect through transcriptional activation of numerous target genes controlling cell cycle arrest, apoptosis, cellular senescence and DNA repair. In addition, there is evidence that p53 influences… read more here.
Keywords: translation; target genes; p53; activation ... See more keywords