Identification of 3-Phenylquinoline Derivative PQ1 as an Antagonist of p53 Transcriptional Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05891
Abstract: Transcription factor p53 regulates cellular responses to environmental perturbations via the transcriptional activation of downstream target genes. Inappropriate p53 activation can trigger abnormal cellular responses, therefore leading to acute or chronic tissue damage, human developmental… read more here.
Keywords: pq1; p53 transcriptional; transcriptional activity; p53 ... See more keywords
Loss of the E6AP Ubiquitin Ligase Induces p53-Dependent Phosphorylation of Human Papillomavirus 18 E6 in Cells Derived from Cervical Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01503-21
Abstract: This study demonstrates that the knockdown of E6AP from cervical cancer-derived cells leads to an increase in phosphorylation of the E6 oncoprotein. We show that this phosphorylation of E6 requires p53 transcriptional activity and the… read more here.
Keywords: cervical cancer; p53 transcriptional; transcriptional activity; phosphorylation ... See more keywords