Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumour cells
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DOI: 10.1080/14756366.2021.1919890
Abstract: Abstract In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalysing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated.… read more here.
Keywords: p5c reductase; tumour cells; phenyl substituted; proline ... See more keywords