p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy
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DOI: 10.1002/2211-5463.12385
Abstract: Autophagy is a bulk degradation pathway, and selective autophagy to remove foreign entities is called xenophagy. The conjugation of ubiquitin to target pathogens is an important process in xenophagy but when and where this ubiquitination… read more here.
Keywords: ubiquitin conjugation; p62; endosome rupture; target ... See more keywords
Subsarcolemmal and cytoplasmic p62 positivity and rimmed vacuoles are distinctive for PLIN4 ‐myopathy
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51666
Abstract: PLIN4‐myopathy is a recently identified autosomal dominant muscular disorder caused by the coding 99 bp repeat expansion in PLIN4, presenting with distal or proximal weakness. Here, we report one family and one sporadic case of adult‐onset… read more here.
Keywords: rimmed vacuoles; plin4 myopathy; subsarcolemmal cytoplasmic; p62 ... See more keywords
p62/sequestosome 1 in human colorectal carcinoma as a potent prognostic predictor associated with cell proliferation
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DOI: 10.1002/cam4.1093
Abstract: p62/sequestosome 1 (p62) is a multi‐domain protein that functions as a receptor for ubiquitinated targets in the selective autophagy and serves as a scaffold in various signaling cascades. p62 have been reported to be up‐regulated… read more here.
Keywords: cell proliferation; p62; colorectal carcinoma;
The unique Akt inhibitor SC66 suppressed AMPK activity and abolished autophagy through the EGFR‐p62 pathway
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DOI: 10.1002/cbin.11732
Abstract: Akt is usually considered to be a negative regulator of both autophagy and adenosine 5′‐monophosphate (AMP)‐activated protein kinase (AMPK) signaling. In the present study, we found that SC66, a pyridine‐based allosteric Akt inhibitor, suppressed basal… read more here.
Keywords: p62; akt inhibitor; sc66; akt ... See more keywords
tert‐Butylhydroquinone‐induced formation of high‐molecular‐weight p62: A novel mechanism in the activation of Nrf2‐Keap1
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DOI: 10.1002/cbin.11849
Abstract: The respiratory system is always exposed to air and is most vulnerable to attack by environmental free radicals. The nuclear factor E2‐related factor 2–Kelch‐like ECH‐associated protein 1–antioxidant response element (Nrf2‐Keap1‐ARE) pathway and p62 are both… read more here.
Keywords: tert butylhydroquinone; keap1 pathway; nrf2 keap1; p62 ... See more keywords
Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1–mediated p62/sequestosome 1 phosphorylation
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29742
Abstract: Obesity commonly leads to hepatic steatosis, which often provokes lipotoxic injuries to hepatocytes that cause nonalcoholic steatohepatitis (NASH). NASH, in turn, is associated with the accumulation of insoluble protein aggregates that are composed of ubiquitinated… read more here.
Keywords: protein; lipotoxicity; p62; p62 sequestosome ... See more keywords
Loss of p62 impairs bone turnover and inhibits PTH‐induced osteogenesis
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DOI: 10.1002/jcp.29654
Abstract: The p62 (also named sequestosome1/SQSTM1) is multidomain and multifunctional protein associated with several physiological and pathological conditions. A number of studies evidenced an involvement of p62 on the disruptive bone scenarios due to its participation… read more here.
Keywords: loss p62; turnover; p62; bone ... See more keywords
Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity
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DOI: 10.1007/s10565-020-09528-2
Abstract: Sirtuin 6 (Sirt6) is important for maintaining kidney homeostasis and function. Cd exposure increases the risk of developing kidney diseases. However, the role of Sirt6 in kidney disease mechanisms is unclear. Here, we evaluated the… read more here.
Keywords: apoptosis; treatment; p62; role ... See more keywords
Ginsenoside Rd ameliorates colitis by inducing p62‐driven mitophagy‐mediated NLRP3 inflammasome inactivation in mice
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DOI: 10.1016/j.bcp.2018.07.010
Abstract: Graphical abstract Figure. No caption available. &NA; Previous studies reported that Ginsenoside Rd (Rd) had anti‐inflammatory and anti‐cancer effects. However, the molecular mechanism underlying the inhibition effect of Rd on colitis in mice hasn't been… read more here.
Keywords: ginsenoside ameliorates; colitis inducing; p62; mice ... See more keywords
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy.
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DOI: 10.1016/j.bcp.2021.114837
Abstract: Rupture and permeabilization of endocytic vesicles can be triggered by various causes, such as pathogenic invasions, amyloid proteins, and silica crystals leading to cell death and degeneration. A cellular quality control process, called lysophagy was… read more here.
Keywords: low dose; photodynamic therapy; p62; autophagy ... See more keywords
Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila.
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DOI: 10.1016/j.celrep.2019.06.070
Abstract: Autophagy, a lysosomal degradation pathway, plays crucial roles in health and disease. p62/SQSTM1 (hereafter p62) is an autophagy adaptor protein that can shuttle ubiquitinated cargo for autophagic degradation. Here, we show that upregulating the Drosophila… read more here.
Keywords: p62 sqstm1; health; p62; autophagy adaptor ... See more keywords