ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.09.001
Abstract: Tumors undergo nutrient stress and need to reprogram their metabolism to survive. The stroma may play a critical role in this process by providing nutrients to support the epithelial compartment of the tumor. Here we… read more here.
Keywords: vulnerability p62; synthetic vulnerability; stroma; p62 deficient ... See more keywords
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARĪ³
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DOI: 10.1038/s41467-021-23085-0
Abstract: Activation of non-shivering thermogenesis is considered a promising approach to lower body weight in obesity. p62 deficiency in adipocytes reduces systemic energy expenditure but its role in sustaining mitochondrial function and thermogenesis remains unresolved. NBR1… read more here.
Keywords: nbr1 critical; p62; p62 deficient; deficient adipocytes ... See more keywords