p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118884
Abstract: AIMS Growing evidence indicates insufficient autophagy is crucial to airway remodeling in asthma. However, it is uncertain whether p62, an autophagy major regulator, mediates the airway remodeling process. This study aimed to evaluate the role… read more here.
Keywords: muscle cells; p62 dependent; smooth muscle; airway remodeling ... See more keywords
Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-024-00739-3
Abstract: Background Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people in the developed world, and the number of people affected is expected to almost double by 2040. The retina presents one… read more here.
Keywords: p62 dependent; dependent lysophagy; promotes p62; urolithin promotes ... See more keywords
YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB
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DOI: 10.7554/elife.22416
Abstract: The ubiquitin ligase TRAF6 is a key regulator of canonical IκB kinase (IKK)/NF-κB signaling in response to interleukin-1 (IL-1) stimulation. Here, we identified the deubiquitinating enzyme YOD1 (OTUD2) as a novel interactor of TRAF6 in… read more here.
Keywords: p62 dependent; traf6; traf6 association; yod1 ... See more keywords