Garcinia cambogia attenuates adipogenesis by affecting CEBPB and SQSTM1/p62-mediated selective autophagic degradation of KLF3 through RPS6KA1 and STAT3 suppression.
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DOI: 10.1080/15548627.2021.1936356
Abstract: The overexpansion of adipose tissues leads to obesity and eventually results in metabolic disorders. Garcinia cambogia (G. cambogia) has been used as an antiobesity supplement. However, the molecular mechanisms underlying the effects of G. cambogia… read more here.
Keywords: cambogia; sqstm1 p62; cebpb; mediated selective ... See more keywords
VDR/Atg3 axis regulates slit diaphragm to tight junction transition via p62-mediated autophagy pathway in diabetic nephropathy.
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DOI: 10.2337/db21-0205
Abstract: Foot process effacement is an important feature of early diabetic nephropathy (DN) which is closely related to the development of albuminuria. Under certain nephrotic conditions, the integrity and function of the glomerular slit diaphragm (SD)… read more here.
Keywords: transition; slit diaphragm; autophagic flux; diabetic nephropathy ... See more keywords