Degradation of helicase-like transcription factor (HLTF) by β-TrCP promotes hepatocarcinogenesis via activation of the p62/mTOR axis.
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DOI: 10.1093/jmcb/mjad012
Abstract: Helicase-like transcription factor (HLTF) has been found to be involved in the maintenance of genome stability and tumour suppression, but whether its downregulation in cancers is associated with posttranslational regulation remains unclear. Here, we observed… read more here.
Keywords: trcp; hcc; hltf; p62 mtor ... See more keywords