Abstract 1868: Upregulation of p62/Nrf2 and downregulation of p-eIF2a provide more susceptible to docosahexaenoic acid-induced cell death in LMP-1 expressing nasopnaryngeal carcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1868
Abstract: Docosahexaenoic acid (DHA) induces apoptotic cell death through several mechanisms in cancer cells. We have previously demonstrated that DHA triggers apoptosis by increasing reactive oxygen species (ROS) accumulation and the ROS-mediated apoptosis caused by DHA… read more here.
Keywords: dha; p62 nrf2; cell; cell death ... See more keywords
Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis
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DOI: 10.1538/expanim.17-0112
Abstract: Nonalcoholic steatohepatitis (NASH) is one of the leading causes of chronic liver disease worldwide. However, details of pathogenetic mechanisms remain unknown. Deletion of both p62/Sqstm1 and Nrf2 genes spontaneously led to the development of NASH… read more here.
Keywords: nonalcoholic steatohepatitis; p62 nrf2; mice; deletion p62 ... See more keywords
p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases
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DOI: 10.3390/brainsci10110847
Abstract: Turnover of the mitochondrial pool due to coordinated processes of mitochondrial biogenesis and mitophagy is an important process in maintaining mitochondrial stability. An important role in this process is played by the Nrf2/ARE signaling pathway,… read more here.
Keywords: regulatory loop; p62; p62 nrf2; nrf2 p62 ... See more keywords