Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0640-7_30
Abstract: Cerebral cavernous malformations (CCM) is a familial or sporadic rare disorder that is characterized by capillary vascular lesions with a mulberry-like appearance on MRI scans. Three distinct genes have been associated to CCM disease, known… read more here.
Keywords: p62 sqstm1; immunofluorescence; ccm disease; detection p62 ... See more keywords
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.11.008
Abstract: Modulators of mRNA stability are not well understood in melanoma, an aggressive tumor with complex changes in the transcriptome. Here we report the ability of p62/SQSTM1 to extend mRNA half-life of a spectrum of pro-metastatic… read more here.
Keywords: metastatic factors; p62 sqstm1; sqstm1 fuels; pro metastatic ... See more keywords
Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.06.070
Abstract: Autophagy, a lysosomal degradation pathway, plays crucial roles in health and disease. p62/SQSTM1 (hereafter p62) is an autophagy adaptor protein that can shuttle ubiquitinated cargo for autophagic degradation. Here, we show that upregulating the Drosophila… read more here.
Keywords: p62 sqstm1; health; p62; autophagy adaptor ... See more keywords
Polyubiquitination of p62/SQSTM1 is a prerequisite for Fas/CD95 aggregation to promote caspase-dependent apoptosis in cadmium-exposed mouse monocyte RAW264.7 cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48684-2
Abstract: Cadmium(Cd) induces cytotoxicity via autophagy-induced apoptosis in non-activated mouse monocytes; however, the molecular mechanism remains unclear. Here, we show that autophagy induces Fas (CD95/APO-1)-mediated apoptosis by promoting accumulation of p62/SQSTM1 in response to Cd. Cd… read more here.
Keywords: fas; apoptosis; polyub; p62 sqstm1 ... See more keywords
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13615
Abstract: Intracellular accumulation of filamentous tau aggregates with progressive neuronal loss is a common characteristic of tauopathies. Although the neurodegenerative mechanism of tau‐associated pathology remains unclear, molecular elements capable of degrading and/or sequestering neurotoxic tau species… read more here.
Keywords: p62 sqstm1; tau; accumulation; mice ... See more keywords
Hydroxyurea Exhibits Antioxidant Activity Via the Nrf2 Pathway- Antioxidant/Electrophile Response Element Regulated By p62/ SQSTM1
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-117220
Abstract: Introduction: The pathophysiology of sickle cell anemia (HF) is characterized by hemolytic and intermittent vasoconstrictive events with increased redox status in the vascular microenvironment that favors the chronic inflammation. Objectives: To investigate whether hydroxyurea (HU)… read more here.
Keywords: response; p62 sqstm1; expression; hemin ... See more keywords
Relevance of FXR-p62/SQSTM1 pathway for survival and protection of mouse hepatocytes and liver, especially with steatosis
Sign Up to like & getrecommendations! Published in 2017 at "BMC Gastroenterology"
DOI: 10.1186/s12876-016-0568-3
Abstract: BackgroundLiver injury and regeneration involve complicated processes and are affected by various physio-pathological conditions. Surgically, severe liver injury after surgical resection often leads to fatal liver failure, especially with some underlying pathological conditions such as… read more here.
Keywords: fxr; protection; p62 sqstm1; steatosis ... See more keywords
Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0201621
Abstract: To cope with intrinsic and environmental stress, cancer cells rely on adaptive pathways more than non-transformed counterparts. Such non-oncogene addiction offers new therapeutic targets and strategies to overcome chemoresistance. In an attempt to study the… read more here.
Keywords: accumulation; chemoresistance; epithelial cancer; p62 sqstm1 ... See more keywords
NBR1‐mediated p62‐liquid droplets enhance the Keap1‐Nrf2 system
Sign Up to like & getrecommendations! Published in 2020 at "EMBO reports"
DOI: 10.15252/embr.201948902
Abstract: p62/SQSTM1 is a multivalent protein that has the ability to cause liquid–liquid phase separation and serves as a receptor protein that participates in cargo isolation during selective autophagy. This protein is also involved in the… read more here.
Keywords: keap1 nrf2; p62 sqstm1; nrf2 system; p62 liquid ... See more keywords
BioID reveals an ATG9A interaction with ATG13‐ATG101 in the degradation of p62/SQSTM1‐ubiquitin clusters
Sign Up to like & getrecommendations! Published in 2021 at "EMBO reports"
DOI: 10.15252/embr.202051136
Abstract: ATG9A, the only multi‐pass transmembrane protein among core ATG proteins, is an essential regulator of autophagy, yet its regulatory mechanisms and network of interactions are poorly understood. Through quantitative BioID proteomics, we identify a network… read more here.
Keywords: sqstm1 ubiquitin; p62 sqstm1; bioid reveals; atg13 atg101 ... See more keywords
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.793328
Abstract: Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and… read more here.
Keywords: p62 sqstm1; autophagy receptor; selective autophagy; p62 ... See more keywords