Dominant TP63 missense variants lead to constitutive activation and premature ovarian insufficiency
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24432
Abstract: Premature ovarian insufficiency (POI) is a leading form of female infertility, characterised by menstrual disturbance and elevated follicle‐stimulating hormone before age 40. It is highly heterogeneous with variants in over 80 genes potentially causative, but… read more here.
Keywords: poi; p63; tp63; missense variants ... See more keywords
Master regulatory role of p63 in epidermal development and disease
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2701-z
Abstract: The transcription factor p63 is a master regulator of epidermal development. Mutations in p63 give rise to human developmental diseases that often manifest epidermal defects. In this review, we summarize major p63 isoforms identified so… read more here.
Keywords: regulatory role; p63 epidermal; epidermal development; p63 ... See more keywords
p63 isoforms in triple-negative breast cancer: ΔNp63 associates with the basal phenotype whereas TAp63 associates with androgen receptor, lack of BRCA mutation, PTEN and improved survival
Sign Up to like & getrecommendations! Published in 2018 at "Virchows Archiv"
DOI: 10.1007/s00428-018-2324-2
Abstract: The TP63 gene encodes two major protein variants that differ in their N-terminal sequences and have opposing effects. In breast, ΔNp63 is expressed by immature stem/progenitor cells and mature myoepithelial/basal cells and is a characteristic… read more here.
Keywords: breast; p63 isoforms; p63; np63 ... See more keywords
p63 Expression in Merkel Cell Carcinoma: Comparative immunohistochemistry invokes TAp63 as the dominant isoform involved.
Sign Up to like & getrecommendations! Published in 2020 at "Human pathology"
DOI: 10.1016/j.humpath.2020.01.001
Abstract: The literature suggests that p63 expression in Merkel cell carcinoma (MCC) is associated with a poor prognosis. p63 immunohistochemistry marks the two main isoforms of this transcriptional protein, TAp63 (tumor-suppressor-like properties) and ∆Np63 (oncogenic properties).… read more here.
Keywords: immunohistochemistry; expression merkel; isoform; p63 ... See more keywords
HMGB1 enhances epithelial permeability via p63/TGF-β signaling in lung and terminal bronchial epithelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Tissue Barriers"
DOI: 10.1080/21688370.2020.1805997
Abstract: ABSTRACT High mobility group box 1 (HMGB1) is involved in the induction of airway inflammation and injury in patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). HMGB1 increased by transforming growth… read more here.
Keywords: hmgb1; p63; cldn; permeability ... See more keywords
Can p40 (Polyclonal) Replace p63 (Clone 4A4) in the Cytologic Diagnosis of Pulmonary Non–Small Cell Carcinoma?
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqx031
Abstract: Objectives Differentiating squamous cell carcinoma from adenocarcinoma (ACA) in cytology specimens can be challenging. Recent literature showed p40 had higher specificity than p63 for this purpose. Methods We identified 190 cytology cases with p40 (polyclonal)… read more here.
Keywords: cell carcinoma; p63; clone 4a4; p40 polyclonal ... See more keywords
Evolutionary re-wiring of p63 and the epigenomic regulatory landscape in keratinocytes and its potential implications on species-specific gene expression and phenotypes
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx416
Abstract: Abstract Although epidermal keratinocyte development and differentiation proceeds in similar fashion between humans and mice, evolutionary pressures have also wrought significant species-specific physiological differences. These differences between species could arise in part, by the rewiring… read more here.
Keywords: p63; landscape; mouse human; p63 binding ... See more keywords
Utility of p63 and PTEN Staining in Distinguishing Cervical Microglandular Hyperplasia from Endometrial Endometrioid Carcinoma with Microglandular/Mucinous Features.
Sign Up to like & getrecommendations! Published in 2022 at "Histopathology"
DOI: 10.1111/his.14655
Abstract: AIMS Distinction between well-differentiated endometrial carcinoma (EMCA) with microglandular/mucinous features and benign endocervical microglandular hyperplasia (MGH) can be a diagnostic challenge, especially when tissue is limited. The immunostains used to distinguish endocervical and endometrial carcinoma… read more here.
Keywords: p63; microglandular hyperplasia; carcinoma; mucinous features ... See more keywords
Functional Conservation of Divergent p63-Bound cis-Regulatory Elements
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00339
Abstract: The transcription factor p63 is an essential regulator of vertebrate ectoderm development, including epidermis, limbs, and craniofacial tissues. Here, we have investigated the evolutionary conservation of p63 binding sites (BSs) between zebrafish and human. First,… read more here.
Keywords: functional conservation; p63 bound; p63; conservation ... See more keywords
Comparison of p63 immunohistochemistry and shear wave elastography in the diagnosis of indeterminate breast lesions: A prospective study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_2038_21
Abstract: Purpose: To evaluate the accuracy of breast shear wave elastography (SWE) and p63 immunohistochemistry (IHC) in the diagnosis of indeterminate breast lesions. Methods: Based on detailed clinical examination and a combination of X-ray mammography/B-mode ultrasound… read more here.
Keywords: p63 ihc; p63; diagnosis; breast ... See more keywords
Immunoexpression of TTF1 and p63 Differentiates Lung Adenocarcinomas in Sputum Samples
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cytology"
DOI: 10.4103/joc.joc_252_16
Abstract: Context: Differentiating NSCLC as either adeno or squamous type and identification of Epidermal Growth Factor Receptor (EGFR) mutations is clinically relevant for lung cancer patients for selecting treatment. Thyroid transcription factor-1 (TTF-1) and p63 were… read more here.
Keywords: p63; sputum samples; expression; lung cancer ... See more keywords