Delineating functional mechanisms of the p53/p63/p73 family of transcription factors through identification of protein–protein interactions using interface mimicry
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DOI: 10.1002/mc.23405
Abstract: Members of the p53 family of transcription factors—p53, p63, and p73—share a high degree of homology; however, members can be activated in response to different stimuli, perform distinct (sometimes opposing) roles and are expressed in… read more here.
Keywords: family; p53 p63; transcription factors; p63 p73 ... See more keywords
p53, p63 and p73 in the wonderland of S. cerevisiae
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DOI: 10.18632/oncotarget.18506
Abstract: Since its discovery in 1979, p53 has been on the forefront of cancer research. It is considered a master gene of cancer suppression and is found mutated in around 50% of all human tumors. In… read more here.
Keywords: p53; p63 p73; p73 wonderland; p53 p63 ... See more keywords
The p53 Family Members p63 and p73 Roles in the Metastatic Dissemination: Interactions with microRNAs and TGFβ Pathway
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DOI: 10.3390/cancers14235948
Abstract: Simple Summary The p53 protein family is a class of proteins successively known to be the guardians of the genome, but also depending on the different isoforms have pro-tumoral and pro-metastatic potential. This dual potential… read more here.
Keywords: family; family members; metastatic spread; p53 family ... See more keywords