SOCS3 protects against neonatal necrotizing enterocolitis via suppressing NLRP3 and AIM2 inflammasome activation and p65 nuclear translocation.
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DOI: 10.1016/j.molimm.2020.03.019
Abstract: BACKGROUND Necrotizing enterocolitis (NEC) is an acquired disorder of mucosal damage characterized by the diffuse or local necrosis of the intestine. The suppressor of cytokine signaling 3 (SOCS3) has been demonstrated to possess anti-inflammatory action… read more here.
Keywords: aim2 inflammasome; socs3; p65 nuclear; nlrp3 aim2 ... See more keywords
Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα
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DOI: 10.2147/dddt.s238695
Abstract: Background Ubiquitin-fold modifier-1 (Ufm1) is a recently identified ubiquitin-like protein. We previously confirmed that Ufm1 expression was increased in diabetic mice. However, its role in the development of diabetes remains undefined. Methods Lentivirus-mediated gene knockdown… read more here.
Keywords: p65 nuclear; ubiquitin fold; ubiquitination degradation; nuclear translocation ... See more keywords