MiR-124 attenuates doxorubicin-induced cardiac injury via inhibiting p66Shc-mediated oxidative stress.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.157
Abstract: Previous studies showed that miR-124 had a protective role by reducing oxidant stress and preventing cell apoptosis and autophagy. However, its role in doxorubicin-induced cardiomyopathy was less known. In our study, we confirmed increased ROS… read more here.
Keywords: 124 attenuates; doxorubicin induced; stress; p66shc ... See more keywords
SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.02.015
Abstract: Findings concerning the role of diabetes mellitus (DM) in osteoclast differentiation are contradictory in vivo and in vitro. Sirtuin 1 (SIRT1) can inhibit RANKL-induced osteoclastogenesis and deacetylate p66Shc suppress its phosphorylation in high glucose (HG)-stimulated human umbilical… read more here.
Keywords: sirt1; osteoclast differentiation; high glucose; differentiation ... See more keywords
p66Shc promotes HCC progression in the tumor microenvironment via STAT3 signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111550
Abstract: The development of hepatocellular carcinoma (HCC) is strongly associated with chronic inflammation. p66Shc is an oxidase previously shown to promote androgen-independent cell growth through generation of reactive oxygen species. However, the importance and biologic functions… read more here.
Keywords: hcc; promotes hcc; stat3; p66shc promotes ... See more keywords
p66Shc activation promotes increased oxidative phosphorylation and renders CNS cells more vulnerable to amyloid beta toxicity
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35114-y
Abstract: A key pathological feature of Alzheimer’s disease (AD) is the accumulation of the neurotoxic amyloid beta (Aβ) peptide within the brains of affected individuals. Previous studies have shown that neuronal cells selected for resistance to… read more here.
Keywords: amyloid beta; toxicity; expression; p66shc ... See more keywords
Knockdown of p66Shc Alters Lineage-Associated Transcription Factor Expression in Mouse Blastocysts
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cells and Development"
DOI: 10.1089/scd.2018.0131
Abstract: The p66Shc adaptor protein regulates apoptosis and senescence during early mammalian development. However, p66Shc expression during mouse preimplantation development is upregulated at the blastocyst stage. Our objective was to determine the biological function of p66Shc… read more here.
Keywords: associated transcription; expression; p66shc; lineage associated ... See more keywords
Deletion of p66Shc dysregulates ERK and STAT3 activity in embryonic stem cells, enhancing their naïve-like self-renewal in the presence of LIF.
Sign Up to like & getrecommendations! Published in 2023 at "Stem cells and development"
DOI: 10.1089/scd.2022.0283
Abstract: The ShcA adapter protein is necessary for early embryonic development. The role of ShcA in development is primarily attributed to its 52kDa and 46kDa isoforms, that transduce receptor tyrosine kinase (RTK) signaling via the extracellular… read more here.
Keywords: p66shc; development; self renewal; activity ... See more keywords
Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehx615
Abstract: Aims Accumulation of reactive oxygen species (ROS) promotes vascular disease in obesity, but the underlying molecular mechanisms remain poorly understood. The adaptor p66Shc is emerging as a key molecule responsible for ROS generation and vascular… read more here.
Keywords: obesity; jmjd2c src; p66shc; suv39h1 jmjd2c ... See more keywords
Western style diet-induced lipid peroxidation is associated with upregulation of p66shc signaling
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5729650
Abstract: Background: Obesity is one of the leading risks for death worldwide due to numerous comorbidity diseases. One of the primary causes for obesity and related metabolic disorders is related to the western-style (high-fat high-sucrose) diet… read more here.
Keywords: p66shc; western style; hfhsd; physiology ... See more keywords
Cadmium Chloride Induces Memory Deficits and Hippocampal Damage by Activating the JNK/p66Shc/NADPH Oxidase Axis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Toxicology"
DOI: 10.1177/1091581820930651
Abstract: This study investigated whether the mechanism underlying the neurotoxic effects of cadmium chloride (CdCl2) in rats involves p66Shc. This study comprised an initial in vivo experiment followed by an in vitro experiment. For the in… read more here.
Keywords: nadph oxidase; cadmium chloride; p66shc; jnk ... See more keywords
Physical activity pacifies the problematic p66Shc
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Preventive Cardiology"
DOI: 10.1177/2047487319886139
Abstract: The impaired capacity of vasculature to adjust to changes in blood flow is a contributing factor in myocardial ischemia, infarction and subsequent dysfunction. With age and other co-morbid conditions, the ability of vascular beds to… read more here.
Keywords: epigenetic modifications; activity associated; p66shc; function ... See more keywords
Regulation of the pulmonary vascular tone by p66shc and cyclophilin D
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/1393003.congress-2017.oa4659
Abstract: Mitochondria regulate intracellular calcium homeostasis and thereby may affect pulmonary vascular functions, in particular the response of the pulmonary vasculature to hypoxia. We investigated whether the proteins p66shc and cyclophilin D (CypD), which regulate release… read more here.
Keywords: p66shc cyclophilin; pulmonary vascular; vascular tone; p66shc cypd ... See more keywords