A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105965
Abstract: Survival and expansion of malignant B cells in chronic lymphocytic leukemia (CLL) are highly dependent both on intrinsic defects in the apoptotic machinery and on the interactions with cells and soluble factors in the lymphoid… read more here.
Keywords: p66shc expression; cll; cll cells; oxazepine based ... See more keywords
Prenatal nicotine exposure leads to decreased histone H3 lysine 9 (H3K9) methylation and increased p66shc expression in the neonatal pancreas
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174421000283
Abstract: Abstract Prenatal exposure to nicotine, tobacco’s major addictive constituent, has been shown to reduce birth weight and increases apoptosis, oxidative stress, and mitochondrial dysfunction in the postnatal pancreas. Given that upregulated levels of the pro-oxidative… read more here.
Keywords: expression; p66shc expression; increased p66shc; histone lysine ... See more keywords
P66Shc expression in diabetic rat retina
Sign Up to like & getrecommendations! Published in 2018 at "BMC Ophthalmology"
DOI: 10.1186/s12886-018-0724-3
Abstract: BackgroundP66Shc is partially localised within the mitochondrial fraction. It is primarily related to the generation of mitochondrial reactive oxygen species and apoptosis. Based on previous studies, we hypothesize that in the retina, p66Shc may exist… read more here.
Keywords: p66shc expression; layer; expression; retina p66shc ... See more keywords