p70S6K on astrocytes protects dopamine neurons from 1‐methyl‐4‐phenylpyridinium neurotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24013
Abstract: Our recent finding has demonstrated that astrocytes confer neuroprotection by endogenously producing ciliary neurotrophic factor (CNTF) via transient receptor potential vanilloid 1 (TRPV1) in Parkinson's disease (PD). In this study, the possible molecular target for… read more here.
Keywords: trpv1; p70s6k signaling; p70s6k astrocytes; p70s6k ... See more keywords
Nck1 promotes the progression of ovarian carcinoma by enhancing the PI3K/AKT/p70S6K signaling
Sign Up to like & getrecommendations! Published in 2020 at "Human Cell"
DOI: 10.1007/s13577-020-00344-8
Abstract: Non-catalytic region of tyrosine kinase adaptor protein 1 (Nck1) is crucial for the progression of cancers. However, little is known on the role of Nck1 in the progression of ovarian carcinoma (OC). Here, we show… read more here.
Keywords: nck1 expression; akt p70s6k; pi3k akt; p70s6k ... See more keywords
Phosphorylation of p70 Ribosomal Protein S6 Kinase &bgr;‐1 is an Independent Prognostic Parameter in Metastatic Colorectal Cancer
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DOI: 10.1016/j.clcc.2018.02.003
Abstract: Background Deregulation of signal transduction pathways plays a critical role in oncogenesis of colorectal cancer (CRC) and directly affects sensitivity to targeted therapies. Against this background we developed a comprehensive biomarker profiling program including markers… read more here.
Keywords: p70s6k; colorectal cancer; phosphorylation; protein kinase ... See more keywords