Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway
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DOI: 10.1016/j.apsb.2021.03.031
Abstract: Abstract The mammalian target of rapamycin (mTOR)-sterol regulatory element-binding proteins (SREBPs) signaling promotes lipogenesis. However, mTOR inhibitors also displayed a significant side effect of hyperlipidemia. Thus, it is essential to develop mTOR-specific inhibitors to inhibit… read more here.
Keywords: srebps pathway; hyperlipidemia; p70s6k srebps; mtor ... See more keywords