A FRET‐Based Fluorescent Probe to Screen Anticancer Drugs, Inhibiting p73 Binding to MDM2
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000660
Abstract: The protein p73 acts as a transcription factor, resulting in tumour suppression. MDM2, an oncogenic protein, can negatively influence p73‐mediated apoptosis by binding to p73 transactivation domains (TAD). Inhibition of the protein‐protein interaction between p73… read more here.
Keywords: protein; p73; fret probe; probe ... See more keywords
p73-Governed miRNA Networks: Translating Bioinformatics Approaches to Therapeutic Solutions for Cancer Metastasis.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8982-9_2
Abstract: The transcription factor p73 synthesizes a large number of isoforms and presents high structural and functional homology with p53, a well-known tumor suppressor and a famous "Holy Grail" of anticancer targeting. p73 has attracted increasing… read more here.
Keywords: p73; transcription; governed mirna; bioinformatics approaches ... See more keywords
TAp73 upregulates IL-1β in cancer cells: Potential biomarker in lung and breast cancer?
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2016.10.085
Abstract: p73 is a transcription factor belonging to the p53 tumour suppressor family. p73−/− mice exhibit a range of phenotypes including neurological, reproductive and inflammatory defects. Although the role of p73 in the control of genomic… read more here.
Keywords: p73; tap73 upregulates; breast; inflammatory response ... See more keywords
The NUPR1/p73 axis contributes to sorafenib resistance in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.07.026
Abstract: The multikinase inhibitor sorafenib was the first drug approved by the FDA for treating patients with advanced hepatocellular carcinoma (HCC). However, sorafenib resistance remains a major challenge for improving the effectiveness of HCC treatment. Previously,… read more here.
Keywords: hepatocellular carcinoma; p73; hcc; treatment ... See more keywords
p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion
Sign Up to like & getrecommendations! Published in 2018 at "iScience"
DOI: 10.1016/j.isci.2018.09.018
Abstract: Summary We report that p73 is expressed in ovarian granulosa cells and that loss of p73 leads to attenuated follicle development, ovulation, and corpus luteum formation, resulting in decreased levels of circulating progesterone and defects… read more here.
Keywords: p73; cell; follicle development; cell adhesion ... See more keywords
p73 – NAV3 axis plays a critical role in suppression of colon cancer metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Oncogenesis"
DOI: 10.1038/s41389-020-0193-4
Abstract: p73 is a member of the p53 tumor suppressor family, which transactivates p53-responsive genes and mediates DNA damage response. Recent evidences suggest that p73 exerts its tumor suppressor functions by suppressing metastasis, but the exact… read more here.
Keywords: p73; metastasis; colon cancer; role ... See more keywords
Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00826-x
Abstract: Excessive exposure to UVB induces skin diseases. Silibinin, a flavonolignan used for treating liver diseases, is found to be effective against UVB-caused skin epidermal and dermal cell damage. In this study we investigated the molecular… read more here.
Keywords: yap p73; p73 pathway; p73; silibinin ... See more keywords
p73 coordinates with Δ133p53 to promote DNA double-strand break repair
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-018-0085-8
Abstract: Tumour repressor p53 isoform Δ133p53 is a target gene of p53 and an antagonist of p53-mediated apoptotic activity. We recently demonstrated that Δ133p53 promotes DNA double-strand break (DSB) repair by upregulating transcription of the repair… read more here.
Keywords: p73; promote dna; strand; p53 ... See more keywords
p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123202119
Abstract: Significance p73 is expressed as multiple C-terminal isoforms, but their expression and activity are largely unknown. Here, we identified p73α1 as a p73 C-terminal isoform that results from exon 12 (E12) exclusion. We showed that… read more here.
Keywords: p73 p73; p73; tumor suppression; terminal isoform ... See more keywords
Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aao4170
Abstract: Contrary to previous reports, wild-type p53 can interact with p73 to promote cell stress–induced apoptosis. Another look at p53-p73 interactions The transcription factor p53 critically regulates cell survival or death in response to cellular stress.… read more here.
Keywords: p73; type p53; p53; cell ... See more keywords
GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.228684
Abstract: ABSTRACT A distinct combination of transcription factors elicits the acquisition of a specific fate and the initiation of a differentiation program. Multiciliated cells (MCCs) are a specialized type of epithelial cells that possess dozens of… read more here.
Keywords: activation p73; p73; governs multiciliogenesis; gemc1 governs ... See more keywords